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    Uri1 URI1, prefoldin-like chaperone [ Mus musculus (house mouse) ]

    Gene ID: 19777, updated on 3-Dec-2024

    Summary

    Official Symbol
    Uri1provided by MGI
    Official Full Name
    URI1, prefoldin-like chaperoneprovided by MGI
    Primary source
    MGI:MGI:1342294
    See related
    Ensembl:ENSMUSG00000030421 AllianceGenome:MGI:1342294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rmp; NNX3
    Summary
    Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of phosphatase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Is expressed in several structures, including alimentary system; brain; epithelium; genitourinary system; and muscle tissue. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.9), bladder adult (RPKM 10.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Uri1 in Genome Data Viewer
    Location:
    7 B3; 7 25.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (37659417..37722989, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (37959992..38023564, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 536 Neighboring gene RIKEN cDNA 4930505M18 gene Neighboring gene STARR-seq mESC enhancer starr_18671 Neighboring gene predicted gene, 22302 Neighboring gene STARR-positive B cell enhancer ABC_E8166 Neighboring gene STARR-positive B cell enhancer ABC_E6537 Neighboring gene STARR-seq mESC enhancer starr_18677 Neighboring gene predicted gene, 30684 Neighboring gene STARR-positive B cell enhancer ABC_E8167 Neighboring gene STARR-positive B cell enhancer ABC_E4920 Neighboring gene predicted gene, 30771 Neighboring gene cyclin E1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to steroid hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    unconventional prefoldin RPB5 interactor
    Names
    RNA polymerase II subunit 5-mediating protein
    RPB5-mediating protein
    protein phosphatase 1 regulatory subunit 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417201.1NP_001404130.1  unconventional prefoldin RPB5 interactor isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163447
      UniProtKB/TrEMBL
      A0A0U1RPG9
    2. NM_001417202.1NP_001404131.1  unconventional prefoldin RPB5 interactor isoform b

      Status: VALIDATED

      Source sequence(s)
      AC163447
      UniProtKB/TrEMBL
      A0A0U1RPG9
    3. NM_011274.6NP_035404.4  unconventional prefoldin RPB5 interactor isoform a

      See identical proteins and their annotated locations for NP_035404.4

      Status: VALIDATED

      Source sequence(s)
      AC163447
      Consensus CDS
      CCDS21157.1
      UniProtKB/Swiss-Prot
      Q3TLD5, Q3V078, Q8R5C4, Q9Z243
      UniProtKB/TrEMBL
      A0A0U1RPG9
      Related
      ENSMUSP00000082646.5, ENSMUST00000085513.6
      Conserved Domains (1) summary
      cl09111
      Location:36145
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      37659417..37722989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539676.3XP_006539739.2  unconventional prefoldin RPB5 interactor isoform X1

      UniProtKB/TrEMBL
      A0A0U1RNX4
      Related
      ENSMUSP00000145738.2, ENSMUST00000206581.2
      Conserved Domains (1) summary
      cl09111
      Location:48150
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_006539677.4XP_006539740.1  unconventional prefoldin RPB5 interactor isoform X2

      UniProtKB/TrEMBL
      A0A0U1RPG9
      Conserved Domains (1) summary
      cl09111
      Location:899
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...