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    Ckmt1 creatine kinase, mitochondrial 1, ubiquitous [ Mus musculus (house mouse) ]

    Gene ID: 12716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ckmt1provided by MGI
    Official Full Name
    creatine kinase, mitochondrial 1, ubiquitousprovided by MGI
    Primary source
    MGI:MGI:99441
    See related
    Ensembl:ENSMUSG00000000308 AllianceGenome:MGI:99441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mt-CK; mi-CK; U-MtCK; mia-CK; ScCKmit; UbCKmit
    Summary
    Predicted to enable creatine kinase activity and identical protein binding activity. Involved in negative regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; sensory organ; and urinary system. Orthologous to human CKMT1A (creatine kinase, mitochondrial 1A) and CKMT1B (creatine kinase, mitochondrial 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 828.0), duodenum adult (RPKM 727.8) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ckmt1 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121188257..121194218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121357773..121363737)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 4 Neighboring gene transformation related protein 53 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_05522 Neighboring gene STARR-seq mESC enhancer starr_05523 Neighboring gene STARR-positive B cell enhancer ABC_E2640 Neighboring gene STARR-seq mESC enhancer starr_05524 Neighboring gene STARR-positive B cell enhancer ABC_E5972 Neighboring gene STARR-seq mESC enhancer starr_05525 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E640 Neighboring gene predicted gene, 33947 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene elongation factor RNA polymerase II-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables creatine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner-outer membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    creatine kinase U-type, mitochondrial
    Names
    acidic-type mitochondrial creatine kinase
    ubiquitous mitochondrial creatine kinase
    NP_001341998.1
    NP_001403881.1
    NP_001403882.1
    NP_001403883.1
    NP_001403884.1
    NP_001403885.1
    NP_001403886.1
    NP_034027.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355069.1NP_001341998.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845466
      Consensus CDS
      CCDS16640.1
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7
      Related
      ENSMUSP00000077349.3, ENSMUST00000078222.9
      Conserved Domains (1) summary
      cd00716
      Location:50407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
    2. NM_001416952.1NP_001403881.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845466
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7
    3. NM_001416953.1NP_001403882.1  creatine kinase U-type, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845466
    4. NM_001416954.1NP_001403883.1  creatine kinase U-type, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845466
    5. NM_001416955.1NP_001403884.1  creatine kinase U-type, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845466
    6. NM_001416956.1NP_001403885.1  creatine kinase U-type, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845466
    7. NM_001416957.1NP_001403886.1  creatine kinase U-type, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845466
    8. NM_009897.4NP_034027.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_034027.1

      Status: VALIDATED

      Source sequence(s)
      AL845466
      Consensus CDS
      CCDS16640.1
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7
      Related
      ENSMUSP00000000317.6, ENSMUST00000000317.13
      Conserved Domains (1) summary
      cd00716
      Location:50407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121188257..121194218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)