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    Naca nascent polypeptide-associated complex alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 17938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nacaprovided by MGI
    Official Full Name
    nascent polypeptide-associated complex alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:106095
    See related
    Ensembl:ENSMUSG00000061315 AllianceGenome:MGI:106095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    skNAC; Gm1878; mKIAA0363
    Summary
    Enables TBP-class protein binding activity and transcription coactivator activity. Acts upstream of or within myoblast migration. Located in cytoplasm and nucleus. Is expressed in several structures, including aorta; genitourinary system; gut; liver; and spleen. Orthologous to human NACA (nascent polypeptide associated complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 34.3), CNS E11.5 (RPKM 24.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Naca in Genome Data Viewer
    Location:
    10 D3; 10 76.39 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127869144..127884506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128035346..128048637)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene prostaglandin E synthase 3 Neighboring gene predicted gene, 47438 Neighboring gene STARR-positive B cell enhancer ABC_E25 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nascent polypeptide-associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nascent polypeptide-associated complex subunit alpha
    Names
    alpha-NAC, muscle-specific form
    alpha-NAC/1.9.2
    nascent polypeptide-associated complex alpha subunit
    nascent polypeptide-associated complex subunit alpha, muscle-specific form
    NP_001106670.1
    NP_001269905.1
    NP_038636.2
    XP_036011564.1
    XP_036011565.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113199.2NP_001106670.1  nascent polypeptide-associated complex subunit alpha isoform a

      See identical proteins and their annotated locations for NP_001106670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS48723.1
      UniProtKB/Swiss-Prot
      E9QMB1, P70670
      Related
      ENSMUSP00000089680.6, ENSMUST00000092048.13
      Conserved Domains (3) summary
      PHA03247
      Location:10571559
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:21412186
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:20562103
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    2. NM_001282976.2NP_001269905.1  nascent polypeptide-associated complex subunit alpha isoform b

      See identical proteins and their annotated locations for NP_001269905.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 5' UTR and lacks an in-frame large exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS24258.1
      UniProtKB/Swiss-Prot
      Q3THR6, Q4FZL8, Q60817
      UniProtKB/TrEMBL
      Q3UK68
      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    3. NM_013608.4NP_038636.2  nascent polypeptide-associated complex subunit alpha isoform b

      See identical proteins and their annotated locations for NP_038636.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame large exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS24258.1
      UniProtKB/Swiss-Prot
      Q3THR6, Q4FZL8, Q60817
      UniProtKB/TrEMBL
      Q3UK68
      Related
      ENSMUSP00000073532.8, ENSMUST00000073868.9
      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127869144..127884506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155672.1XP_036011565.1  nascent polypeptide-associated complex subunit alpha isoform X2

      UniProtKB/Swiss-Prot
      Q3THR6, Q4FZL8, Q60817
      UniProtKB/TrEMBL
      Q3UK68
      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    2. XM_036155671.1XP_036011564.1  nascent polypeptide-associated complex subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      E9QMB1, P70670
      Conserved Domains (3) summary
      PHA03247
      Location:10571559
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:21412186
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:20562103
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit