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    nanY 2,7-anhydro-N-acetylneuraminate hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948808, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nanY
    Official Full Name
    2,7-anhydro-N-acetylneuraminate hydratase
    Primary source
    ECOCYC:G7901
    Locus tag
    b4280
    See related
    ASAP:ABE-0014027
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4270; yjhC
    Summary
    YjhC may be involved in metabolism of sialic acid; see . [More information is available at EcoCyc: G7901].
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    Genomic context

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    Sequence:
    NC_000913.3 (4505287..4506405)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene IS4 family putative transposase Neighboring gene sialic acid transporter NanX Neighboring gene uncharacterized protein YthA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases. Kentache T, et al. Biosci Rep, 2020 Jun 26. PMID 32542330, Free PMC Article
    2. On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism. Horne CR, et al. Proteins, 2020 May. PMID 31697432
    3. Distant cis-active sequences and sialic acid control the expression of fimB in Escherichia coli K-12. El-Labany S, et al. Mol Microbiol, 2003 Aug. PMID 12890032
    4. Studying protein complexes by the yeast two-hybrid system. Rajagopala SV, et al. Methods, 2012 Dec. PMID 22841565, Free PMC Article
    5. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism.
      Title: On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2,7-anhydro-N-acetylneuraminate hydratase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4505287..4506405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418700.2 2,7-anhydro-N-acetylneuraminate hydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418700.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0B0VHQ2, A0A828TYP3
      Conserved Domains (1) summary
      COG0673
      Location:1 → 364
      MviM; Predicted dehydrogenase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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