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    Xpot exportin, tRNA (nuclear export receptor for tRNAs) [ Mus musculus (house mouse) ]

    Gene ID: 73192, updated on 3-Dec-2024

    Summary

    Official Symbol
    Xpotprovided by MGI
    Official Full Name
    exportin, tRNA (nuclear export receptor for tRNAs)provided by MGI
    Primary source
    MGI:MGI:1920442
    See related
    Ensembl:ENSMUSG00000034667 AllianceGenome:MGI:1920442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EXPORTIN-T; 1110004L07Rik; 3110065H13Rik
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in several structures, including endocrine gland; female reproductive system; mammary gland; oral epithelium; and trigeminal nerve. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.2), liver E14 (RPKM 10.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Xpot in Genome Data Viewer
    Location:
    10 D2; 10 69.86 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121423285..121462411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121587380..121626506, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35696 Neighboring gene TANK-binding kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1129 Neighboring gene STARR-positive B cell enhancer ABC_E9355 Neighboring gene STARR-seq mESC enhancer starr_28102 Neighboring gene predicted gene, 35816 Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene STARR-seq mESC enhancer starr_28105 Neighboring gene predicted gene, 35865

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA re-export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exportin-T
    Names
    exportin(tRNA)
    tRNA exportin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081056.3NP_001074525.1  exportin-T isoform 1

      See identical proteins and their annotated locations for NP_001074525.1

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      Consensus CDS
      CCDS88093.1
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      UniProtKB/TrEMBL
      A0A1W2P7Q6
      Related
      ENSMUSP00000151722.2, ENSMUST00000218004.2
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100247
      Xpo1; Exportin 1-like protein
    2. NM_001359618.2NP_001346547.1  exportin-T isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      Consensus CDS
      CCDS88093.1
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      UniProtKB/TrEMBL
      A0A1W2P7Q6
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100247
      Xpo1; Exportin 1-like protein
    3. NM_001401044.1NP_001387973.1  exportin-T isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
    4. NM_001401045.1NP_001387974.1  exportin-T isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      121423285..121462411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245308.1XP_030101168.1  exportin-T isoform X3

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (1) summary
      pfam08389
      Location:6137
      Xpo1; Exportin 1-like protein
    2. XM_006514208.5XP_006514271.1  exportin-T isoform X3

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (1) summary
      pfam08389
      Location:6137
      Xpo1; Exportin 1-like protein
    3. XM_030245306.2XP_030101166.1  exportin-T isoform X1

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98245
      Xpo1; Exportin 1-like protein
    4. XM_006514206.4XP_006514269.1  exportin-T isoform X1

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98245
      Xpo1; Exportin 1-like protein
    5. XM_006514207.5XP_006514270.1  exportin-T isoform X2

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100247
      Xpo1; Exportin 1-like protein