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    Rnh1 ribonuclease/angiogenin inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107702, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnh1provided by MGI
    Official Full Name
    ribonuclease/angiogenin inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1195456
    See related
    Ensembl:ENSMUSG00000038650 AllianceGenome:MGI:1195456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNH
    Summary
    Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of angiogenesis. Predicted to be located in cytosol. Predicted to be part of angiogenin-PRI complex. Predicted to be active in several cellular components, including lamellipodium; nucleoplasm; and plasma membrane. Is expressed in bladder; blood; embryo; pancreas; and yolk sac. Orthologous to human RNH1 (ribonuclease/angiogenin inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 94.0), adrenal adult (RPKM 89.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rnh1 in Genome Data Viewer
    Location:
    7 F5; 7 86.44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140740239..140752764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141160326..141172851, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene phosphatidylserine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E8222 Neighboring gene STARR-positive B cell enhancer ABC_E9715 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonuclease inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of angiogenin-PRI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of angiogenin-PRI complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172100.1NP_001165571.1  ribonuclease inhibitor isoform a

      See identical proteins and their annotated locations for NP_001165571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
      Source sequence(s)
      AK141351, BY114445, BY574079
      Consensus CDS
      CCDS22002.1
      UniProtKB/Swiss-Prot
      Q91VI7, Q924P4
      UniProtKB/TrEMBL
      Q3UM23
      Related
      ENSMUSP00000133061.2, ENSMUST00000167493.9
      Conserved Domains (3) summary
      smart00368
      Location:335362
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:1320
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:224
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_001172101.1NP_001165572.1  ribonuclease inhibitor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' splice pattern and uses a distinct start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AK141351, BY085526, BY574079
      Consensus CDS
      CCDS85455.1
      UniProtKB/TrEMBL
      A0A1B0GSG5, Q3UM23
      Related
      ENSMUSP00000147928.2, ENSMUST00000210314.2
      Conserved Domains (4) summary
      smart00368
      Location:371398
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      COG4886
      Location:46361
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:37356
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:3860
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_145135.3NP_660117.2  ribonuclease inhibitor isoform a

      See identical proteins and their annotated locations for NP_660117.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
      Source sequence(s)
      AK141351, BM946973, BY574079
      Consensus CDS
      CCDS22002.1
      UniProtKB/Swiss-Prot
      Q91VI7, Q924P4
      UniProtKB/TrEMBL
      Q3UM23
      Related
      ENSMUSP00000101651.4, ENSMUST00000106033.5
      Conserved Domains (3) summary
      smart00368
      Location:335362
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:1320
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:224
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140740239..140752764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)