U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Socs5 suppressor of cytokine signaling 5 [ Mus musculus (house mouse) ]

    Gene ID: 56468, updated on 9-Dec-2024

    Summary

    Official Symbol
    Socs5provided by MGI
    Official Full Name
    suppressor of cytokine signaling 5provided by MGI
    Primary source
    MGI:MGI:2385459
    See related
    Ensembl:ENSMUSG00000037104 AllianceGenome:MGI:2385459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cish5; mKIAA0671; 1810018L08Rik
    Summary
    Enables epidermal growth factor receptor binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; negative regulation of cytokine production; and regulation of T-helper cell differentiation. Acts upstream of or within epidermal growth factor receptor signaling pathway. Is expressed in retina. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.1), cortex adult (RPKM 11.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Socs5 in Genome Data Viewer
    Location:
    17 E4; 17 56.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87414707..87445153)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87107278..87137647)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24648 Neighboring gene thioredoxin domain containing 14 pseudogene Neighboring gene predicted gene, 30510 Neighboring gene STARR-positive B cell enhancer mm9_chr17:87506617-87506918 Neighboring gene STARR-positive B cell enhancer mm9_chr17:87518269-87518569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:87552369-87552639 Neighboring gene predicted gene, 53968 Neighboring gene RIKEN cDNA C330024C12 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0671

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to low-density lipoprotein particle stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell activation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotactic protein-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T-helper 1 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial cell response to fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    suppressor of cytokine signaling 5
    Names
    SOCS-5
    cytokine inducible SH2-containing protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019654.2NP_062628.2  suppressor of cytokine signaling 5

      See identical proteins and their annotated locations for NP_062628.2

      Status: PROVISIONAL

      Source sequence(s)
      BC053015
      Consensus CDS
      CCDS29014.1
      UniProtKB/Swiss-Prot
      O54928, Q7TSK1
      Related
      ENSMUSP00000038591.7, ENSMUST00000041369.8
      Conserved Domains (3) summary
      cd03739
      Location:479534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370470
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      87414707..87445153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524674.5XP_006524737.1  suppressor of cytokine signaling 5 isoform X1

      See identical proteins and their annotated locations for XP_006524737.1

      UniProtKB/Swiss-Prot
      O54928, Q7TSK1
      Conserved Domains (3) summary
      cd03739
      Location:479534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370470
      SH2; Src homology 2 (SH2) domain
    2. XM_006524671.5XP_006524734.1  suppressor of cytokine signaling 5 isoform X1

      See identical proteins and their annotated locations for XP_006524734.1

      UniProtKB/Swiss-Prot
      O54928, Q7TSK1
      Conserved Domains (3) summary
      cd03739
      Location:479534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370470
      SH2; Src homology 2 (SH2) domain
    3. XM_006524672.5XP_006524735.1  suppressor of cytokine signaling 5 isoform X1

      See identical proteins and their annotated locations for XP_006524735.1

      UniProtKB/Swiss-Prot
      O54928, Q7TSK1
      Conserved Domains (3) summary
      cd03739
      Location:479534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370470
      SH2; Src homology 2 (SH2) domain
    4. XM_006524675.5XP_006524738.1  suppressor of cytokine signaling 5 isoform X1

      See identical proteins and their annotated locations for XP_006524738.1

      UniProtKB/Swiss-Prot
      O54928, Q7TSK1
      Conserved Domains (3) summary
      cd03739
      Location:479534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370470
      SH2; Src homology 2 (SH2) domain