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    ppx exopolyphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946970, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ppx
    Official Full Name
    exopolyphosphatase
    Primary source
    ECOCYC:EG11403
    Locus tag
    b2502
    See related
    ASAP:ABE-0008238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2498
    Summary
    PDB structure from O157:H7 has identical sequence as K-12. [More information is available at EcoGene: EG11403]. Exopolyphosphatase (PPX) degrades inorganic polyphosphates (polyP). [More information is available at EcoCyc: EG11403].
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    Genomic context

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    Sequence:
    NC_000913.3 (2625115..2626656)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase Neighboring gene cyclic di-GMP phosphodiesterase PdeF Neighboring gene nickel/cobalt stress response protein YfgG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach. Boetsch C, et al. Arch Biochem Biophys, 2016 Sep 15. PMID 27424154
    2. [Irreversible specific inhibition of E. coli inorganic pyrophosphatase with amines]. Burobin AV, et al. Bioorg Khim, 1997 Feb. PMID 9157843
    3. Guanosine tetra- and pentaphosphate promote accumulation of inorganic polyphosphate in Escherichia coli. Kuroda A, et al. J Biol Chem, 1997 Aug 22. PMID 9261133
    4. The effect of monovalent ions on polyphosphate binding to Escherichia coli exopolyphosphatase. Bolesch DG, et al. Biochem Biophys Res Commun, 2000 Jul 21. PMID 10903924
    5. Polyphosphate binding and chain length recognition of Escherichia coli exopolyphosphatase. Bolesch DG, et al. J Biol Chem, 2000 Oct 27. PMID 10922361

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H(378) is a fundamental gatekeeper for the recognition of long chain polyphosphate
      Title: Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables exopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exopolyphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exopolyphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorus metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within polyphosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exopolyphosphatase
    NP_416997.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2625115..2626656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416997.1 exopolyphosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416997.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ATD1, A0A8S7F3A2
      Conserved Domains (1) summary
      PRK10854
      Location:1 → 513
      PRK10854; exopolyphosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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