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    Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [ Mus musculus (house mouse) ]

    Gene ID: 15382, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hnrnpa1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A1provided by MGI
    Primary source
    MGI:MGI:104820
    See related
    Ensembl:ENSMUSG00000046434 AllianceGenome:MGI:104820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hdp; HDP-1; Hnrpa1; hnRNP A1; hnrnp-A1
    Summary
    Predicted to enable identical protein binding activity; nucleic acid binding activity; and protein domain specific binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome. Located in nucleus. Is active in synapse. Is expressed in several structures, including 1-cell stage embryo; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 643.9), CNS E14 (RPKM 307.8) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hnrnpa1 in Genome Data Viewer
    Location:
    15 F3; 15 58.58 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103148840..103155119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103239943..103246698)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:102993642-102993943 Neighboring gene single-strand selective monofunctional uracil DNA glycosylase Neighboring gene STARR-seq mESC enhancer starr_39867 Neighboring gene chromobox 5 Neighboring gene STARR-seq mESC enhancer starr_39868 Neighboring gene STARR-seq mESC enhancer starr_39872 Neighboring gene nuclear factor, erythroid derived 2 Neighboring gene STARR-positive B cell enhancer ABC_E81 Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene microRNA 148b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102127, MGC102128, MGC103392, D15Ertd119e

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA strand annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric repeat-containing RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to potassium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sodium arsenite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear export ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasmic periphery of the nuclear pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein A1
    Names
    helix-destabilizing protein
    hnRNP core protein A1
    single-strand-binding protein
    topoisomerase-inhibitor suppressed

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039129.5NP_001034218.1  heterogeneous nuclear ribonucleoprotein A1 isoform b

      See identical proteins and their annotated locations for NP_001034218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).
      Source sequence(s)
      AC164069
      Consensus CDS
      CCDS37232.1
      UniProtKB/TrEMBL
      Q3U7F3, Q5EBP8
      Related
      ENSMUSP00000042658.10, ENSMUST00000036004.16
      Conserved Domains (3) summary
      cd12580
      Location:105181
      RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
      cd12761
      Location:1292
      RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
      pfam11627
      Location:310345
      HnRNPA1; Nuclear factor hnRNPA1
    2. NM_010447.6NP_034577.1  heterogeneous nuclear ribonucleoprotein A1 isoform a

      See identical proteins and their annotated locations for NP_034577.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the central coding region, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b.
      Source sequence(s)
      AC164069
      Consensus CDS
      CCDS37233.1
      UniProtKB/Swiss-Prot
      P49312, P97312, Q3V269
      UniProtKB/TrEMBL
      Q3TFB1
      Related
      ENSMUSP00000084609.8, ENSMUST00000087351.9
      Conserved Domains (3) summary
      pfam11627
      Location:255292
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:105184
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12761
      Location:1292
      RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

    RNA

    1. NR_104427.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164069
    2. NR_177200.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164069

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103148840..103155119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)