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    lldP lactate/glycolate:H(+) symporter LldP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948114, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lldP
    Official Full Name
    lactate/glycolate:H(+) symporter LldP
    Primary source
    ECOCYC:EG11961
    Locus tag
    b3603
    See related
    ASAP:ABE-0011777
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3593; lct; lctP
    Summary
    IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11961]. LctP is a probable lactate/proton symporter responsible for the uptake of L-lactate. [More information is available at EcoCyc: EG11961].
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    Genomic context

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    Sequence:
    NC_000913.3 (3777399..3779054)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YibT Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation. Erwin AL, et al. J Bacteriol, 1996 Aug. PMID 8759842, Free PMC Article
    2. Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Núñez MF, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785976
    3. Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli. Aguilera L, et al. J Bacteriol, 2008 Apr. PMID 18263722, Free PMC Article
    4. Mapping the xyl, mtl, and lct loci in Escherichia coli K-12. Lin RJ, et al. J Bacteriol, 1983 Nov. PMID 6313625, Free PMC Article
    5. Vinylglycolate resistance in Escherichia coli. Shaw L, et al. J Bacteriol, 1975 Mar. PMID 1090585, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
      Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycolate transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables lactate transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables lactate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glycolate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lactate transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in lactate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lactate/glycolate:H(+) symporter LldP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3777399..3779054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418060.1 lactate/glycolate:H(+) symporter LldP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418060.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6ZX80
      Conserved Domains (1) summary
      PRK10420
      Location:1 → 551
      PRK10420; L-lactate permease; Provisional
    Nucleotide Protein
    Heading Accession and Version

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