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    Dnaaf5 dynein, axonemal assembly factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 433956, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dnaaf5provided by MGI
    Official Full Name
    dynein, axonemal assembly factor 5provided by MGI
    Primary source
    MGI:MGI:3616079
    See related
    Ensembl:ENSMUSG00000025857 AllianceGenome:MGI:3616079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Heatr2
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium movement; inner dynein arm assembly; and outer dynein arm assembly. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Used to study male infertility and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 18. Orthologous to human DNAAF5 (dynein axonemal assembly factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.8), ovary adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnaaf5 in Genome Data Viewer
    Location:
    5 G2; 5 78.02 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139135888..139172265)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139150133..139186510)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38726 Neighboring gene RIKEN cDNA 6330403L08 gene Neighboring gene STARR-seq mESC enhancer starr_14679 Neighboring gene platelet derived growth factor, alpha Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC60818

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dynein axonemal assembly factor 5
    Names
    HEAT repeat-containing protein 2
    dynein assembly factor 5, axonemal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081265.2NP_001074734.1  dynein axonemal assembly factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001074734.1

      Status: VALIDATED

      Source sequence(s)
      AC125065
      Consensus CDS
      CCDS39349.1
      UniProtKB/Swiss-Prot
      B9EJR8
      Related
      ENSMUSP00000026975.7, ENSMUST00000026975.11
      Conserved Domains (2) summary
      pfam13830
      Location:41198
      DUF4192; Domain of unknown function (DUF4192)
      sd00044
      Location:165193
      HEAT; HEAT repeat [structural motif]
    2. NM_001363485.1NP_001350414.1  dynein axonemal assembly factor 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC158066, BG228650, CK627764
      Consensus CDS
      CCDS90005.1
      UniProtKB/TrEMBL
      B2RY24
      Related
      ENSMUSP00000142924.2, ENSMUST00000196441.2
      Conserved Domains (1) summary
      sd00044
      Location:405433
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139135888..139172265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955669.1 RNA Sequence