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    Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 12159, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmp4provided by MGI
    Official Full Name
    bone morphogenetic protein 4provided by MGI
    Primary source
    MGI:MGI:88180
    See related
    Ensembl:ENSMUSG00000021835 AllianceGenome:MGI:88180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in bladder adult (RPKM 26.3), lung adult (RPKM 20.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bmp4 in Genome Data Viewer
    Location:
    14 C1; 14 23.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46620982..46628126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46383525..46390669, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53856 Neighboring gene ubiquitin B, pseudogene Neighboring gene predicted gene, 34499 Neighboring gene STARR-seq mESC enhancer starr_36560 Neighboring gene Bmp4 promoter region Neighboring gene predicted gene 15217 Neighboring gene predicted gene 15222 Neighboring gene Bmp4 enhancer ECR2 Neighboring gene predicted gene, 34756 Neighboring gene RIKEN cDNA E130120K24 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (20)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables BMP receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables co-receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of ameloblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within anatomical structure development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aortic valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in apoptotic process involved in endocardial cushion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within bone development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in ureteric bud morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within bronchus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within bud dilation involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within bud elongation involved in lung branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in cardiac jelly development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cranial suture morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in deltoid tuberosity development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal joint morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT involved_in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within epithelial-mesenchymal cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epithelium development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerular capillary formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart induction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart induction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intermediate mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intermediate mesodermal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within lens induction in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in lung vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymphoid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphoid progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membranous septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within metanephros development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in muscular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glomerulus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of immature T cell proliferation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation involved in ureter development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation involved in ureter development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of metanephric S-shaped body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of metanephric S-shaped body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of metanephric comma-shaped body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of metanephric comma-shaped body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of prostatic bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of prostatic bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of thymocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in nephric duct formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nephric duct formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neural tube closure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pericyte cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of SMAD protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mesenchymal stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of odontoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_positive_effect positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of prostatic bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pulmonary valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mesodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mesodermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in secondary heart field specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secondary heart field specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within specification of animal organ position IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in specification of segmental identity, mandibular segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon regionalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon regionalization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in tendon cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within trachea development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within trachea formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type B pancreatic cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ureter morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bone morphogenetic protein 4
    Names
    bone morphogenetic protein 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316360.1NP_001303289.1  bone morphogenetic protein 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136527, AK145359, CT009556
      Consensus CDS
      CCDS36897.1
      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Related
      ENSMUSP00000098242.3, ENSMUST00000100676.3
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
    2. NM_007554.3NP_031580.2  bone morphogenetic protein 4 preproprotein

      See identical proteins and their annotated locations for NP_031580.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136527, AK145359, CT009556
      Consensus CDS
      CCDS36897.1
      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Related
      ENSMUSP00000073720.6, ENSMUST00000074077.12
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      46620982..46628126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)