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    Cachd1 cache domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 320508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cachd1provided by MGI
    Official Full Name
    cache domain containing 1provided by MGI
    Primary source
    MGI:MGI:2444177
    See related
    Ensembl:ENSMUSG00000028532 AllianceGenome:MGI:2444177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vwcd1; mKIAA1573; 1190007F10Rik; B430218L07Rik
    Summary
    Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including genitourinary system; inner ear; lung; tooth; and ventricular layer. Orthologous to human CACHD1 (cache domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 17.5), limb E14.5 (RPKM 16.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cachd1 in Genome Data Viewer
    Location:
    4 C6; 4 45.76 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (100633870..100861741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (100776679..101003749)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12700 Neighboring gene predicted gene, 46888 Neighboring gene STARR-seq mESC enhancer starr_10885 Neighboring gene STARR-seq mESC enhancer starr_10886 Neighboring gene STARR-seq mESC enhancer starr_10887 Neighboring gene STARR-seq mESC enhancer starr_10889 Neighboring gene STARR-seq mESC enhancer starr_10890 Neighboring gene STARR-seq mESC enhancer starr_10892 Neighboring gene STARR-seq mESC enhancer starr_10895 Neighboring gene predicted gene, 35956 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene predicted gene, 22100

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    VWFA and cache domain-containing protein 1
    Names
    cache domain-containing protein 1
    von Willebrand factor type A and cache domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198037.2NP_932154.1  VWFA and cache domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_932154.1

      Status: VALIDATED

      Source sequence(s)
      AL627083, AL670223
      Consensus CDS
      CCDS18391.1
      UniProtKB/Swiss-Prot
      A2A8W3, Q6PDJ1, Q6PFZ0, Q6ZPM4, Q8BNP3
      UniProtKB/TrEMBL
      Z4YK18
      Related
      ENSMUSP00000030257.9, ENSMUST00000030257.15
      Conserved Domains (3) summary
      pfam02743
      Location:470537
      Cache_1; Cache domain
      pfam08399
      Location:103218
      VWA_N; VWA N-terminal
      cl00057
      Location:227422
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      100633870..100861741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)