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    Ube2d3 ubiquitin-conjugating enzyme E2D 3 [ Mus musculus (house mouse) ]

    Gene ID: 66105, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2d3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2D 3provided by MGI
    Primary source
    MGI:MGI:1913355
    See related
    Ensembl:ENSMUSG00000078578 AllianceGenome:MGI:1913355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1100001F19Rik; 9430029A22Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 51.8), placenta adult (RPKM 51.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ube2d3 in Genome Data Viewer
    Location:
    3 G3; 3 62.56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135143993..135173975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135438232..135468214)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene STARR-positive B cell enhancer ABC_E6132 Neighboring gene predicted gene, 30992 Neighboring gene mannosidase, beta A, lysosomal Neighboring gene ornithine decarboxylase antizyme 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K6-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 D3
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme D3
    E2 ubiquitin-conjugating enzyme D3
    ubiquitin carrier protein D3
    ubiquitin-conjugating enzyme E2(17)KB 3
    ubiquitin-conjugating enzyme E2-17 kDa 3
    ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
    ubiquitin-protein ligase D3
    NP_001343523.1
    NP_001343524.1
    NP_001343525.1
    NP_001343526.1
    NP_001343527.1
    NP_079632.1
    XP_036019109.1
    XP_036019110.1
    XP_036019111.1
    XP_036019112.1
    XP_036019113.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356594.1NP_001343523.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK167138
      Consensus CDS
      CCDS38644.1
      UniProtKB/Swiss-Prot
      P61079
      UniProtKB/TrEMBL
      Q3U5V6, Q4QQL2, Q9D1S1
      Related
      ENSMUSP00000101898.4, ENSMUST00000106291.10
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001356595.1NP_001343524.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156618, DV648741
      Consensus CDS
      CCDS38644.1
      UniProtKB/Swiss-Prot
      P61079
      UniProtKB/TrEMBL
      Q3U5V6, Q4QQL2, Q9D1S1
      Related
      ENSMUSP00000143301.2, ENSMUST00000199613.5
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_001356596.1NP_001343525.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK153100
      Consensus CDS
      CCDS38644.1
      UniProtKB/Swiss-Prot
      P61079
      UniProtKB/TrEMBL
      Q3U5V6, Q4QQL2, Q9D1S1
      Related
      ENSMUSP00000130096.2, ENSMUST00000166033.6
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    4. NM_001356597.1NP_001343526.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK165235
      Consensus CDS
      CCDS38644.1
      UniProtKB/Swiss-Prot
      P61079
      UniProtKB/TrEMBL
      Q3U5V6, Q4QQL2, Q9D1S1
      Related
      ENSMUSP00000143065.2, ENSMUST00000197539.5
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    5. NM_001356598.1NP_001343527.1  ubiquitin-conjugating enzyme E2 D3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156618
      UniProtKB/TrEMBL
      A0A494BA56
      Conserved Domains (1) summary
      cl00154
      Location:6110
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    6. NM_025356.5NP_079632.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

      See identical proteins and their annotated locations for NP_079632.1

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK153111
      Consensus CDS
      CCDS38644.1
      UniProtKB/Swiss-Prot
      P61079
      UniProtKB/TrEMBL
      Q3U5V6, Q4QQL2, Q9D1S1
      Related
      ENSMUSP00000143608.2, ENSMUST00000197859.5
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135143993..135173975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163218.1XP_036019111.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JGL0, Q3U5V6, Q9D1S1
      Related
      ENSMUSP00000143606.2, ENSMUST00000197134.3
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_036163219.1XP_036019112.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JGL0, Q3U5V6, Q9D1S1
      Related
      ENSMUSP00000142612.2, ENSMUST00000198685.5
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. XM_036163216.1XP_036019109.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JGL0, Q3U5V6, Q9D1S1
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    4. XM_036163217.1XP_036019110.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JGL0, Q3U5V6, Q9D1S1
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    5. XM_036163220.1XP_036019113.1  ubiquitin-conjugating enzyme E2 D3 isoform X2

      UniProtKB/TrEMBL
      A0A494BA56
      Conserved Domains (1) summary
      cl00154
      Location:6110
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...