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    Sergef secretion regulating guanine nucleotide exchange factor [ Mus musculus (house mouse) ]

    Gene ID: 27414, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sergefprovided by MGI
    Official Full Name
    secretion regulating guanine nucleotide exchange factorprovided by MGI
    Primary source
    MGI:MGI:1351630
    See related
    Ensembl:ENSMUSG00000030839 AllianceGenome:MGI:1351630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gef; Gnef; Gnefr; DelGEF
    Summary
    Predicted to be involved in negative regulation of protein secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; esophagus; and ganglia. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.3), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sergef in Genome Data Viewer
    Location:
    7 B3; 7 30.2 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46092583..46289254, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46443159..46642896, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9691 Neighboring gene myogenic differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4927 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 1 Neighboring gene predicted gene, 22969 Neighboring gene STARR-seq mESC enhancer starr_18863 Neighboring gene STARR-seq mESC enhancer starr_18865 Neighboring gene STARR-seq mESC enhancer starr_18866 Neighboring gene STARR-seq mESC enhancer starr_18867 Neighboring gene tryptophan hydroxylase 1 Neighboring gene serum amyloid A-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Clone Names

    • MGC141208, MGC141209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in negative regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    secretion-regulating guanine nucleotide exchange factor
    Names
    deafness locus-associated putative guanine nucleotide exchange factor
    guanine nucleotide exchange factor (RCC1 related)
    guanine nucleotide exchange factor-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013789.2NP_038817.1  secretion-regulating guanine nucleotide exchange factor

      See identical proteins and their annotated locations for NP_038817.1

      Status: VALIDATED

      Source sequence(s)
      AC090652, AK145819, BY228093
      Consensus CDS
      CCDS21279.1
      UniProtKB/Swiss-Prot
      Q0VDT0, Q3UGM8, Q3UKY0, Q80YD6, Q9QXB7
      Related
      ENSMUSP00000033127.5, ENSMUST00000033127.12
      Conserved Domains (2) summary
      pfam00415
      Location:1764
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:103132
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46092583..46289254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153151.1XP_036009044.1  secretion-regulating guanine nucleotide exchange factor isoform X2

      Conserved Domains (2) summary
      COG5184
      Location:17348
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:334380
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. XM_030242640.2XP_030098500.1  secretion-regulating guanine nucleotide exchange factor isoform X8

      Conserved Domains (1) summary
      COG5184
      Location:17279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    3. XM_006540943.5XP_006541006.1  secretion-regulating guanine nucleotide exchange factor isoform X1

      Conserved Domains (2) summary
      COG5184
      Location:22370
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:356402
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    4. XM_011250869.2XP_011249171.1  secretion-regulating guanine nucleotide exchange factor isoform X5

      See identical proteins and their annotated locations for XP_011249171.1

      Conserved Domains (2) summary
      COG5184
      Location:2255
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:241287
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    5. XM_006540944.4XP_006541007.1  secretion-regulating guanine nucleotide exchange factor isoform X5

      See identical proteins and their annotated locations for XP_006541007.1

      Conserved Domains (2) summary
      COG5184
      Location:2255
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:241287
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    6. XM_030242642.2XP_030098502.1  secretion-regulating guanine nucleotide exchange factor isoform X10

      Conserved Domains (1) summary
      COG5184
      Location:17258
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    7. XM_036153152.1XP_036009045.1  secretion-regulating guanine nucleotide exchange factor isoform X4

      Conserved Domains (1) summary
      COG5184
      Location:17327
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    8. XM_030242641.2XP_030098501.1  secretion-regulating guanine nucleotide exchange factor isoform X9

      Conserved Domains (1) summary
      COG5184
      Location:17279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    9. XM_030242638.2XP_030098498.1  secretion-regulating guanine nucleotide exchange factor isoform X3

      UniProtKB/TrEMBL
      A0A1L1SUM5
      Related
      ENSMUSP00000150835.2, ENSMUST00000216505.2
      Conserved Domains (1) summary
      COG5184
      Location:17348
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    10. XM_036153153.1XP_036009046.1  secretion-regulating guanine nucleotide exchange factor isoform X7

      Conserved Domains (1) summary
      COG5184
      Location:17258
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    11. XM_030242639.2XP_030098499.1  secretion-regulating guanine nucleotide exchange factor isoform X6

      Conserved Domains (1) summary
      COG5184
      Location:17279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RNA

    1. XR_003946486.2 RNA Sequence