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    Iars1 isoleucyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 105148, updated on 27-Nov-2024

    Summary

    Official Symbol
    Iars1provided by MGI
    Official Full Name
    isoleucyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:2145219
    See related
    Ensembl:ENSMUSG00000037851 AllianceGenome:MGI:2145219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILRS; Iars; 2510016L12Rik; E430001P04Rik
    Summary
    Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 23.5), CNS E11.5 (RPKM 22.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iars1 in Genome Data Viewer
    Location:
    13 A5; 13 25.38 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49835606..49887743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49682130..49734267)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene predicted gene, 23482 Neighboring gene sperm motility kinase X-like Neighboring gene predicted gene, 19334

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables isoleucine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables isoleucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables isoleucine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in isoleucyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within isoleucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in isoleucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    IRS
    ileRS
    isoleucine-tRNA synthetase
    isoleucyl-tRNA synthetase, cytoplasmic
    NP_742012.2
    XP_006516889.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172015.3NP_742012.2  isoleucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_742012.2

      Status: VALIDATED

      Source sequence(s)
      AK133856, BB052629, BY139910
      Consensus CDS
      CCDS36659.1
      UniProtKB/Swiss-Prot
      Q6NXK4, Q8BU30
      Related
      ENSMUSP00000132082.2, ENSMUST00000165316.8
      Conserved Domains (1) summary
      PLN02882
      Location:61070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49835606..49887743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516826.3XP_006516889.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006516889.1

      UniProtKB/Swiss-Prot
      Q6NXK4, Q8BU30
      Conserved Domains (1) summary
      PLN02882
      Location:61070
      PLN02882; aminoacyl-tRNA ligase