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    Cript cysteine-rich PDZ-binding protein [ Mus musculus (house mouse) ]

    Gene ID: 56724, updated on 9-Dec-2024

    Summary

    Official Symbol
    Criptprovided by MGI
    Official Full Name
    cysteine-rich PDZ-binding proteinprovided by MGI
    Primary source
    MGI:MGI:1929655
    See related
    Ensembl:ENSMUSG00000024146 AllianceGenome:MGI:1929655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200020A08Rik
    Summary
    Predicted to enable PDZ domain binding activity; microtubule binding activity; and scaffold protein binding activity. Predicted to be involved in several processes, including cytoplasmic microtubule organization; protein localization to microtubule; and regulation of postsynaptic density organization. Predicted to be located in dendrite; neuronal cell body; and postsynaptic density. Predicted to be part of spliceosomal complex. Predicted to be active in dendrite; glutamatergic synapse; and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and retina layer. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 26.6), placenta adult (RPKM 25.0) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cript in Genome Data Viewer
    Location:
    17 E4; 17 56.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87332989..87343236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87025561..87035808)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1948 Neighboring gene STARR-positive B cell enhancer ABC_E1512 Neighboring gene predicted gene, 50012 Neighboring gene ras homolog family member Q Neighboring gene STARR-positive B cell enhancer ABC_E7564 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class F Neighboring gene STARR-positive B cell enhancer ABC_E493 Neighboring gene predicted gene, 30421 Neighboring gene predicted gene, 24648 Neighboring gene thioredoxin domain containing 14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Transposon induced (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic density protein 95 clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic density protein 95 clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cysteine-rich PDZ-binding protein
    Names
    cysteine-rich interactor of PDZ three
    cysteine-rich interactor of PDZ3
    postsynaptic protein Cript

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019936.3NP_064320.1  cysteine-rich PDZ-binding protein

      See identical proteins and their annotated locations for NP_064320.1

      Status: VALIDATED

      Source sequence(s)
      AK004828, AK029409, BY123761
      Consensus CDS
      CCDS29012.1
      UniProtKB/Swiss-Prot
      O70333, Q99LR6, Q9DBP4
      Related
      ENSMUSP00000024959.4, ENSMUST00000024959.10
      Conserved Domains (1) summary
      pfam10235
      Location:1199
      Cript; Microtubule-associated protein CRIPT

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      87332989..87343236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)