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    Cela1 chymotrypsin-like elastase family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 109901, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cela1provided by MGI
    Official Full Name
    chymotrypsin-like elastase family, member 1provided by MGI
    Primary source
    MGI:MGI:95314
    See related
    Ensembl:ENSMUSG00000023031 AllianceGenome:MGI:95314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ela1; Ela-1; PC-TsF; 1810009A17Rik; 1810062B19Rik
    Summary
    Enables serine-type endopeptidase activity. Acts upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Located in collagen-containing extracellular matrix. Is expressed in alveolus epithelium; lung; pancreas; pancreas tip epithelium; and right lung accessory lobe. Orthologous to human CELA1 (chymotrypsin like elastase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 5257.0), spleen adult (RPKM 1973.9) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cela1 in Genome Data Viewer
    Location:
    15 F1; 15 56.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100572303..100585801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100674422..100687920, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small cell adhesion glycoprotein Neighboring gene bridging integrator 2 Neighboring gene microRNA 6961 Neighboring gene STARR-positive B cell enhancer ABC_E311 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E10882 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5518

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within elastin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pancreas morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tissue remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    chymotrypsin-like elastase family member 1
    Names
    elastase 1, pancreatic
    elastase-1
    NP_291090.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033612.2NP_291090.2  chymotrypsin-like elastase family member 1 precursor

      See identical proteins and their annotated locations for NP_291090.2

      Status: VALIDATED

      Source sequence(s)
      AK007392, BP769372, CB951068
      Consensus CDS
      CCDS37213.1
      UniProtKB/Swiss-Prot
      Q91X79, Q9D936, Q9Z1H1
      Related
      ENSMUSP00000023775.8, ENSMUST00000023775.9
      Conserved Domains (2) summary
      smart00020
      Location:26258
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:27262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100572303..100585801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)