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    Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 72508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rps6kb1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1270849
    See related
    Ensembl:ENSMUSG00000020516 AllianceGenome:MGI:1270849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
    Summary
    Enables protein kinase activity. Involved in several processes, including cellular response to type II interferon; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of signal transduction. Located in mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early conceptus; leg muscle; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rps6kb1 in Genome Data Viewer
    Location:
    11 C; 11 51.82 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5258 Neighboring gene predicted gene, 26439 Neighboring gene STARR-positive B cell enhancer ABC_E5259 Neighboring gene STARR-positive B cell enhancer ABC_E3003 Neighboring gene STARR-seq mESC enhancer starr_30268 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene STARR-seq mESC enhancer starr_30269 Neighboring gene STARR-seq mESC enhancer starr_30270 Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene predicted gene 9975

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 4732464A07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral fear response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to insulin stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to type II interferon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within germ cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC2 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of skeletal muscle tissue growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus involved in regulation of muscle adaptation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucagon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase beta-1
    Names
    70 kDa ribosomal protein S6 kinase 1
    p70 S6 kinase alpha
    p70 ribosomal S6 kinase alpha
    ribosomal protein S6 kinase I
    ribosomal protein S6 kinase, 70kD, polypeptide 1
    NP_001107806.1
    NP_001350091.1
    NP_082535.1
    XP_006534378.1
    XP_011247577.1
    XP_011247578.1
    XP_036012907.1
    XP_036012908.1
    XP_036012909.1
    XP_036012910.1
    XP_036012911.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114334.2NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001107806.1

      Status: VALIDATED

      Source sequence(s)
      AK032724, AK135716, AL604063
      Consensus CDS
      CCDS48875.1
      UniProtKB/Swiss-Prot
      Q5SWG1, Q8BSK8, Q8CHX0
      UniProtKB/TrEMBL
      Q3UXD8
      Related
      ENSMUSP00000119715.2, ENSMUST00000154617.8
      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    2. NM_001363162.1NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604063
      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:41363
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    3. NM_028259.4NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

      See identical proteins and their annotated locations for NP_082535.1

      Status: VALIDATED

      Source sequence(s)
      AL604063
      Consensus CDS
      CCDS25201.1
      UniProtKB/TrEMBL
      Q8C3J7
      Related
      ENSMUSP00000053188.3, ENSMUST00000058286.9
      Conserved Domains (1) summary
      cl21453
      Location:94195
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86389695..86435711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157018.1XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:1157
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036157014.1XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036157016.1XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036157017.1XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036157015.1XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/TrEMBL
      Q9CST0
      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011249275.4XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    7. XM_006534315.5XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3UXD8
      Conserved Domains (1) summary
      cd05584
      Location:48336
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    8. XM_011249276.4XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

      Conserved Domains (1) summary
      cd05584
      Location:94409
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    RNA

    1. XR_004937046.1 RNA Sequence

    2. XR_004937048.1 RNA Sequence

    3. XR_004937047.1 RNA Sequence

    4. XR_001780060.3 RNA Sequence

    5. XR_003949511.2 RNA Sequence

    6. XR_003949513.1 RNA Sequence

    7. XR_879743.4 RNA Sequence

    8. XR_004937043.1 RNA Sequence

    9. XR_004937042.1 RNA Sequence

    10. XR_004937044.1 RNA Sequence

    11. XR_004937045.1 RNA Sequence