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    Inpp1 inositol polyphosphate-1-phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 16329, updated on 9-Dec-2024

    Summary

    Official Symbol
    Inpp1provided by MGI
    Official Full Name
    inositol polyphosphate-1-phosphataseprovided by MGI
    Primary source
    MGI:MGI:104848
    See related
    Ensembl:ENSMUSG00000026102 AllianceGenome:MGI:104848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2300002C06Rik
    Summary
    Predicted to enable inositol-1,3,4-trisphosphate 1-phosphatase activity and inositol-1,4-bisphosphate 1-phosphatase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Is expressed in several structures, including nervous system; sensory organ; and skeleton. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.4), CNS E18 (RPKM 4.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Inpp1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52824584..52856847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52785425..52817688, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    inositol polyphosphate 1-phosphatase
    Names
    IPP
    IPPase
    NP_032410.2
    XP_011236743.1
    XP_011236744.1
    XP_036018134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432652.1NP_001419581.1  inositol polyphosphate 1-phosphatase

      Status: VALIDATED

      Source sequence(s)
      AC160762
      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
    2. NM_001432653.1NP_001419582.1  inositol polyphosphate 1-phosphatase

      Status: VALIDATED

      Source sequence(s)
      AC160762
      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
    3. NM_001432654.1NP_001419583.1  inositol polyphosphate 1-phosphatase

      Status: VALIDATED

      Source sequence(s)
      AC160762
      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
    4. NM_008384.3NP_032410.2  inositol polyphosphate 1-phosphatase

      See identical proteins and their annotated locations for NP_032410.2

      Status: VALIDATED

      Source sequence(s)
      AC160762
      Consensus CDS
      CCDS14947.1
      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Related
      ENSMUSP00000027271.3, ENSMUST00000027271.9
      Conserved Domains (1) summary
      cd01640
      Location:4384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52824584..52856847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162241.1XP_036018134.1  inositol polyphosphate 1-phosphatase isoform X1

      Conserved Domains (1) summary
      cd01640
      Location:4384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    2. XM_011238441.3XP_011236743.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011236743.1

      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Conserved Domains (1) summary
      cd01640
      Location:4384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    3. XM_011238442.4XP_011236744.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011236744.1

      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Conserved Domains (1) summary
      cd01640
      Location:4384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...