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    efeB heme-containing peroxidase/deferrochelatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946500, updated on 3-Dec-2024

    Summary

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    Official Symbol
    efeB
    Official Full Name
    heme-containing peroxidase/deferrochelatase
    Primary source
    ECOCYC:EG11735
    Locus tag
    b1019
    See related
    ASAP:ABE-0003451
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1009; ycdB
    Summary
    The EfeUOB tripartite iron transporter is silent in Escherichia coli due to a mutation in EfeU (Cao, 2007). [More information is available at EcoGene: EG11735]. EfeB is a heme-containing component of the EfeUOB ferrous iron transporter. [More information is available at EcoCyc: EG11735].
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    Genomic context

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    Sequence:
    NC_000913.3 (1083376..1084647)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ferrous iron transport system protein EfeO Neighboring gene ATP-binding protein PhoH Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport. Cartron ML, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Jan 1. PMID 17183171, Free PMC Article
    2. Mutants of Escherichia coli K12 permeable to haemin. McConville ML, et al. J Gen Microbiol, 1979 Jul. PMID 387910
    3. Hemin-deficient mutants of Escherichia coli K-12. Săsărman A, et al. J Bacteriol, 1968 Aug. PMID 4877132, Free PMC Article
    4. Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact. Létoffé S, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564607, Free PMC Article
    5. YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins. Sturm A, et al. J Biol Chem, 2006 May 19. PMID 16551627

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YfeX and EfeB are widespread and highly conserved in bacteria. We propose that their physiological function is to retrieve iron from heme.
      Title: Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact.
    2. overexpression, purification, crystallization and structure determination at 2.0 A resolution are reported for the apo form of YcdB.
      Title: Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport.
    3. YcdB from Escherichia coli is a member of a novel class of Tat-dependently translocated hemoproteins
      Title: YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron import into cell EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heme-containing peroxidase/deferrochelatase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1083376..1084647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415538.1 heme-containing peroxidase/deferrochelatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415538.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6PSB9
      Conserved Domains (1) summary
      TIGR01412
      Location:5 → 422
      tat_substr_1; Tat-translocated enzyme
    Nucleotide Protein
    Heading Accession and Version

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