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    Prss23 serine protease 23 [ Mus musculus (house mouse) ]

    Gene ID: 76453, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prss23provided by MGI
    Official Full Name
    serine protease 23provided by MGI
    Primary source
    MGI:MGI:1923703
    See related
    Ensembl:ENSMUSG00000039405 AllianceGenome:MGI:1923703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spuve; 2310046G15Rik; 4930479H08Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular space. Is expressed in several structures, including alimentary system; dentate gyrus subgranular zone; early conceptus; genitourinary system; and skeleton. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 53.0), ovary adult (RPKM 40.2) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prss23 in Genome Data Viewer
    Location:
    7 D3; 7 49.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89156988..89176399, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89507783..89527187, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 135 Neighboring gene expressed sequence AI314278 Neighboring gene frizzled class receptor 4 Neighboring gene STARR-seq mESC enhancer starr_19491 Neighboring gene STARR-seq mESC enhancer starr_19492 Neighboring gene STARR-seq mESC enhancer starr_19493 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53381 Neighboring gene malic enzyme 3, NADP(+)-dependent, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine protease 23
    Names
    protease, serine 23
    NP_001347681.2
    NP_001347682.2
    NP_001347683.2
    NP_001347684.1
    NP_001347685.1
    NP_001371077.2
    NP_001371080.1
    NP_001402962.1
    NP_001402963.1
    NP_083890.2
    XP_036009434.1
    XP_036009435.1
    XP_036009438.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360752.2NP_001347681.2  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Related
      ENSMUSP00000147183.2, ENSMUST00000207932.2
    2. NM_001360753.2NP_001347682.2  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
    3. NM_001360754.2NP_001347683.2  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
    4. NM_001360755.2NP_001347684.1  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      Consensus CDS
      CCDS21442.1
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:146254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. NM_001360756.2NP_001347685.1  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      Consensus CDS
      CCDS21442.1
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:146254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    6. NM_001384148.2NP_001371077.2  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
    7. NM_001384151.2NP_001371080.1  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:146254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    8. NM_001416033.1NP_001402962.1  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
    9. NM_001416034.1NP_001402963.1  serine protease 23 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116326
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
    10. NM_029614.5NP_083890.2  serine protease 23 precursor

      See identical proteins and their annotated locations for NP_083890.2

      Status: VALIDATED

      Source sequence(s)
      AC116326
      Consensus CDS
      CCDS21442.1
      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Related
      ENSMUSP00000045191.6, ENSMUST00000041761.7
      Conserved Domains (1) summary
      cl21584
      Location:146254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89156988..89176399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153541.1XP_036009434.1  serine protease 23 isoform X1

      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:187295
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_036153542.1XP_036009435.1  serine protease 23 isoform X2

      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:154262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_036153545.1XP_036009438.1  serine protease 23 isoform X4

      UniProtKB/Swiss-Prot
      Q544M8, Q8VEG1, Q9D6X6
      UniProtKB/TrEMBL
      Q8BZS4
      Conserved Domains (1) summary
      cl21584
      Location:146254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...