Dctn2 dynactin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctn2provided by MGI
Official Full Name: dynactin 2provided by MGI
Primary source: MGI:MGI:107733
See related: Ensembl:ENSMUSG00000025410 AllianceGenome:MGI:107733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p50; RBP50; DCTN-50; GMP23-48K; 2310042E05Rik; C130077D06Rik
Summary: Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Acts upstream of or within melanosome transport. Located in growth cone. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; nervous system; and reproductive system. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 150.2), adrenal adult (RPKM 99.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127102131..127117828)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127266262..127281959)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.
Title: Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C87049 (e-PCR)
- UniSTS:160051

RH124555 (e-PCR)
- UniSTS:161377

D10Wsu93e (e-PCR), detects polymorphism
- UniSTS:141531

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynactin subunit 2

Names: 50 kDa dynein-associated polypeptide; dynactin complex 50 kDa subunit; growth cone membrane protein 23-48K; p50 dynamitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190453.1 → NP_001177382.1 dynactin subunit 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC144852

Conserved Domains (1) summary

pfam04912
Location:16 → 402

Dynamitin; Dynamitin
NM_001190454.1 → NP_001177383.1 dynactin subunit 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC144852

Conserved Domains (1) summary

pfam04912
Location:16 → 405

Dynamitin; Dynamitin
NM_027151.2 → NP_081427.1 dynactin subunit 2 isoform 3

See identical proteins and their annotated locations for NP_081427.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC144852, AK144464

Consensus CDS

CCDS24234.1

UniProtKB/Swiss-Prot

Q99KJ8

UniProtKB/TrEMBL

Q3TPZ5

Related

ENSMUSP00000026479.10, ENSMUST00000026479.11

Conserved Domains (1) summary

pfam04912
Location:16 → 400

Dynamitin; Dynamitin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127102131..127117828

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514055.4 → XP_006514118.1 dynactin subunit 2 isoform X1

Conserved Domains (1) summary

pfam04912
Location:16 → 401

Dynamitin
XM_036155985.1 → XP_036011878.1 dynactin subunit 2 isoform X2

Conserved Domains (1) summary

pfam04912
Location:2 → 313

Dynamitin