U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lima1 LIM domain and actin binding 1 [ Mus musculus (house mouse) ]

    Gene ID: 65970, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lima1provided by MGI
    Official Full Name
    LIM domain and actin binding 1provided by MGI
    Primary source
    MGI:MGI:1920992
    See related
    Ensembl:ENSMUSG00000023022 AllianceGenome:MGI:1920992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eplin
    Summary
    Enables actin filament binding activity. Involved in several processes, including cholesterol homeostasis; intestinal cholesterol absorption; and ruffle organization. Located in actin cytoskeleton; brush border membrane; and ruffle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 44.8), colon adult (RPKM 23.3) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lima1 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99676351..99773292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99778468..99875477, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99555871-99556054 Neighboring gene cytochrome c oxidase assembly protein 14 Neighboring gene ceramide synthase 5 Neighboring gene VISTA enhancer mm17 Neighboring gene predicted gene, 25897 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene 17057 Neighboring gene STARR-seq mESC enhancer starr_39724 Neighboring gene STARR-seq mESC enhancer starr_39726 Neighboring gene STARR-seq mESC enhancer starr_39729 Neighboring gene predicted gene, 18095 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • D15Ertd366e, 1110021C24Rik, 3526402A12Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin monomer binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal cholesterol absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ruffle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    LIM domain and actin-binding protein 1
    Names
    epithelial protein lost in neoplasm

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113545.2NP_001107017.1  LIM domain and actin-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_001107017.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longer isoform (a).
      Source sequence(s)
      AC134548, AC138177
      Consensus CDS
      CCDS49729.1
      UniProtKB/Swiss-Prot
      Q8K2H0, Q9ERG0, Q9ERG1
      UniProtKB/TrEMBL
      Q8C7S2
      Related
      ENSMUSP00000073371.4, ENSMUST00000073691.5
      Conserved Domains (1) summary
      cd09485
      Location:388440
      LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)
    2. NM_023063.5NP_075550.2  LIM domain and actin-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_075550.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate 5'-terminal exon, lacks part of the 5' coding region, and initiates translation from a downstream start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC134548
      Consensus CDS
      CCDS37206.1
      UniProtKB/TrEMBL
      Q8BT15, Q8CD09
      Related
      ENSMUSP00000104652.3, ENSMUST00000109024.9
      Conserved Domains (1) summary
      cd09485
      Location:228280
      LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)

    RNA

    1. NR_177985.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134548, AC138177

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99676351..99773292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521245.2XP_006521308.1  LIM domain and actin-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cd09485
      Location:101153
      LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)