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    Alb albumin [ Mus musculus (house mouse) ]

    Gene ID: 11657, updated on 9-Dec-2024

    Summary

    Official Symbol
    Albprovided by MGI
    Official Full Name
    albuminprovided by MGI
    Primary source
    MGI:MGI:87991
    See related
    Ensembl:ENSMUSG00000029368 AllianceGenome:MGI:87991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alb1; Alb-1; BCL002
    Summary
    This gene encodes albumin, an abundant plasma protein essential for maintaining oncotic pressure that functions as a carrier protein for various molecules such as steriods and fatty acids in blood. This gene is primarily expressed in liver where the encoded protein undergoes proteolytic processing before secretion into the plasma. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in liver adult (RPKM 14891.4), liver E14.5 (RPKM 6823.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Alb in Genome Data Viewer
    Location:
    5 E1; 5 44.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90608729..90624461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90460870..90476602)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 17 Neighboring gene STARR-seq mESC enhancer starr_13598 Neighboring gene predicted gene 9958 Neighboring gene predicted gene, 35999 Neighboring gene albumin (Alb) 5' regulatory region Neighboring gene alpha fetoprotein (Afp) 5' regulatory region Neighboring gene alpha fetoprotein Neighboring gene afamin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enterobactin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enterobactin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enterobactin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables exogenous protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables exogenous protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables modified amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to oxygen binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to oxygen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxic substance binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    albumin
    Names
    albumin 1
    serum albumin
    NP_033784.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009654.4NP_033784.2  albumin preproprotein

      See identical proteins and their annotated locations for NP_033784.2

      Status: REVIEWED

      Source sequence(s)
      AK131891, BY131635, W41729
      Consensus CDS
      CCDS19412.1
      UniProtKB/Swiss-Prot
      P07724, Q3TV03, Q61802, Q8C7C7, Q8C7H3, Q8CG74
      UniProtKB/TrEMBL
      Q546G4
      Related
      ENSMUSP00000031314.9, ENSMUST00000031314.10
      Conserved Domains (2) summary
      smart00103
      Location:21204
      ALBUMIN; serum albumin
      pfam00273
      Location:223394
      Serum_albumin; Serum albumin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      90608729..90624461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)