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    Adh1 alcohol dehydrogenase 1 (class I) [ Mus musculus (house mouse) ]

    Gene ID: 11522, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adh1provided by MGI
    Official Full Name
    alcohol dehydrogenase 1 (class I)provided by MGI
    Primary source
    MGI:MGI:87921
    See related
    Ensembl:ENSMUSG00000074207 AllianceGenome:MGI:87921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh-1; ADH-A2; ADH-AA; Adh-1e; Adh-1t; Adh-3e; Adh1-e; Adh1-t; Adh1tl; Adh3-e; Adh-1-t
    Summary
    Enables alcohol dehydrogenase (NAD+) activity and identical protein binding activity. Acts upstream of or within several processes, including behavioral response to ethanol; ethanol catabolic process; and retinoid metabolic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; epidermis; genitourinary system; intestine; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to human ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 1139.9), adrenal adult (RPKM 886.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Adh1 in Genome Data Viewer
    Location:
    3 G3; 3 64.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137983346..137996459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138277585..138290698)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Neighboring gene predicted gene, 40156 Neighboring gene Adh1 promoter region Neighboring gene predicted gene 16559 Neighboring gene alcohol dehydrogenase 6A (class V)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables organic cyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ethanol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to steroid hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to testosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retinoic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alcohol dehydrogenase 1
    Names
    alcohol dehydrogenase 1 temporal, liver
    alcohol dehydrogenase 1, complex
    alcohol dehydrogenase 1, electrophoretic
    alcohol dehydrogenase 3, electrophoretic
    alcohol dehydrogenase A subunit
    class I alcohol dehydrogenase
    NP_031435.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007409.3NP_031435.1  alcohol dehydrogenase 1

      See identical proteins and their annotated locations for NP_031435.1

      Status: VALIDATED

      Source sequence(s)
      AC079682, AI256543, AI326887, CD355981, DV044803
      Consensus CDS
      CCDS17867.1
      UniProtKB/Swiss-Prot
      P00329
      UniProtKB/TrEMBL
      Q3UKA4
      Related
      ENSMUSP00000004232.10, ENSMUST00000004232.10
      Conserved Domains (2) summary
      cd08299
      Location:3375
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:8375
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137983346..137996459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)