U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Emcn endomucin [ Mus musculus (house mouse) ]

    Gene ID: 59308, updated on 9-Dec-2024

    Summary

    Official Symbol
    Emcnprovided by MGI
    Official Full Name
    endomucinprovided by MGI
    Primary source
    MGI:MGI:1891716
    See related
    Ensembl:ENSMUSG00000054690 AllianceGenome:MGI:1891716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Muc14; 0610012K22Rik
    Summary
    Predicted to enable carbohydrate binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Is expressed in several structures, including cardiovascular system; early conceptus; hemolymphoid system; lung; and urinary system. Orthologous to human EMCN (endomucin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 46.9), heart adult (RPKM 22.7) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Emcn in Genome Data Viewer
    Location:
    3 G3; 3 63.65 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137046824..137136830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137341062..137431069)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26107 Neighboring gene STARR-seq mESC enhancer starr_09083 Neighboring gene STARR-seq mESC enhancer starr_09084 Neighboring gene STARR-positive B cell enhancer ABC_E9225 Neighboring gene predicted gene 567 Neighboring gene predicted gene, 38650 Neighboring gene STARR-seq mESC enhancer starr_09085 Neighboring gene predicted gene 4861 Neighboring gene DNA-damage-inducible transcript 4-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    endomucin
    Names
    MUC-14
    endomucin-1
    endomucin-1/2
    mucin 14, endothelial
    mucin-14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163522.1NP_001156994.1  endomucin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156994.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA822842, BC003706
      Consensus CDS
      CCDS51075.1
      UniProtKB/Swiss-Prot
      Q78KL2, Q9DCN9, Q9R0H2, Q9ULC1, Q9Z2I1
      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000112603.2, ENSMUST00000122064.8
      Conserved Domains (1) summary
      pfam07010
      Location:1261
      Endomucin; Endomucin
    2. NM_016885.2NP_058581.2  endomucin isoform 2 precursor

      See identical proteins and their annotated locations for NP_058581.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA822842, AK002616, BC003706
      Consensus CDS
      CCDS17861.1
      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000114102.2, ENSMUST00000119475.6
      Conserved Domains (1) summary
      pfam07010
      Location:1248
      Endomucin; Endomucin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137046824..137136830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501842.4XP_006501905.1  endomucin isoform X1

      See identical proteins and their annotated locations for XP_006501905.1

      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000142467.2, ENSMUST00000197511.2
      Conserved Domains (1) summary
      pfam07010
      Location:1223
      Endomucin