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    Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform [ Mus musculus (house mouse) ]

    Gene ID: 19055, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp3caprovided by MGI
    Official Full Name
    protein phosphatase 3, catalytic subunit, alpha isoformprovided by MGI
    Primary source
    MGI:MGI:107164
    See related
    Ensembl:ENSMUSG00000028161 AllianceGenome:MGI:107164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CN; CnA; Caln; Calna; 2900074D19Rik
    Summary
    Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of transport; and regulation of gene expression. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; calcineurin-NFAT signaling cascade; and regulation of DNA-templated transcription. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 101.0), frontal lobe adult (RPKM 75.5) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp3ca in Genome Data Viewer
    Location:
    3 G3; 3 63.34 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (136375778..136643488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (136669714..136937727)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11221 Neighboring gene STARR-seq mESC enhancer starr_09074 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene RIKEN cDNA 1700030L20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1635 Neighboring gene STARR-positive B cell enhancer ABC_E11222 Neighboring gene STARR-seq mESC enhancer starr_09075 Neighboring gene STARR-positive B cell enhancer ABC_E6136 Neighboring gene STARR-seq mESC enhancer starr_09076 Neighboring gene STARR-positive B cell enhancer ABC_E6137 Neighboring gene STARR-seq mESC enhancer starr_09078 Neighboring gene STARR-seq mESC enhancer starr_09079 Neighboring gene RIKEN cDNA 1700006H20 gene Neighboring gene 60S ribosomal protein L36a-like Neighboring gene STARR-seq mESC enhancer starr_09082 Neighboring gene predicted gene, 26107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC106804

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-dependent protein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of calcium ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of connective tissue replacement IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell proliferation involved in kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcineurin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcineurin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein serine/threonine phosphatase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in slit diaphragm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in slit diaphragm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 3 catalytic subunit alpha
    Names
    CAM-PRP catalytic subunit
    CNA alpha
    PP2B alpha 1
    PP2BA alpha
    calcineurin A alpha
    NP_001280551.1
    NP_032939.1
    XP_017174981.1
    XP_017174982.1
    XP_030108322.1
    XP_030108323.1
    XP_030108324.1
    XP_036018837.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293622.2NP_001280551.1  protein phosphatase 3 catalytic subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_001280551.1

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC129775
      Consensus CDS
      CCDS80027.1
      UniProtKB/Swiss-Prot
      P63328
      Related
      ENSMUSP00000071040.8, ENSMUST00000070198.14
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_001428644.1NP_001415573.1  protein phosphatase 3 catalytic subunit alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    3. NM_001428645.1NP_001415574.1  protein phosphatase 3 catalytic subunit alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    4. NM_001428646.1NP_001415575.1  protein phosphatase 3 catalytic subunit alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    5. NM_008913.6NP_032939.1  protein phosphatase 3 catalytic subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_032939.1

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC129775
      Consensus CDS
      CCDS17860.1
      UniProtKB/Swiss-Prot
      B2RRX2, P12816, P20652, P63328, Q3UCU1, Q64135
      Related
      ENSMUSP00000053101.9, ENSMUST00000056758.9
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      136375778..136643488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252463.2XP_030108323.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    2. XM_030252464.2XP_030108324.1  protein phosphatase 3 catalytic subunit alpha isoform X2

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    3. XM_030252462.2XP_030108322.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    4. XM_017319493.3XP_017174982.1  protein phosphatase 3 catalytic subunit alpha isoform X2

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    5. XM_036162944.1XP_036018837.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    6. XM_017319492.3XP_017174981.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain