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    Apof apolipoprotein F [ Mus musculus (house mouse) ]

    Gene ID: 103161, updated on 27-Nov-2024

    Summary

    Official Symbol
    Apofprovided by MGI
    Official Full Name
    apolipoprotein Fprovided by MGI
    Primary source
    MGI:MGI:104539
    See related
    Ensembl:ENSMUSG00000047631 AllianceGenome:MGI:104539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within cholesterol efflux; cholesterol metabolic process; and triglyceride metabolic process. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human APOF (apolipoprotein F). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 507.2) and liver E18 (RPKM 297.1) See more
    Orthologs
    NEW
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    Genomic context

    See Apof in Genome Data Viewer
    Location:
    10 D3; 10 76.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128104568..128107119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128268699..128271250)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26847 Neighboring gene timeless circadian clock 1 Neighboring gene STARR-seq mESC enhancer starr_28273 Neighboring gene apolipoprotein N Neighboring gene STARR-positive B cell enhancer ABC_E5199 Neighboring gene signal transducer and activator of transcription 2 Neighboring gene STARR-seq mESC enhancer starr_28274 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol efflux IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    apolipoprotein F
    Names
    LVIF
    apo-F
    leukemia virus-inactivating factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133997.3NP_598758.2  apolipoprotein F precursor

      Status: VALIDATED

      Source sequence(s)
      AC135859
      Consensus CDS
      CCDS24268.2
      UniProtKB/Swiss-Prot
      Q91V80
      UniProtKB/TrEMBL
      A0A0R4J0M4
      Related
      ENSMUSP00000050300.4, ENSMUST00000050901.5
      Conserved Domains (1) summary
      pfam15148
      Location:53250
      Apolipo_F; Apolipoprotein F

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128104568..128107119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)