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    nuoN NADH:quinone oxidoreductase subunit N [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945136, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nuoN
    Official Full Name
    NADH:quinone oxidoreductase subunit N
    Primary source
    ECOCYC:EG12093
    Locus tag
    b2276
    See related
    ASAP:ABE-0007526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2270
    Summary
    Revised ATG start codon supported by mutagenesis and sequence conservation. [More information is available at EcoGene: EG12093]. NuoN is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG12093].
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    Genomic context

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    Sequence:
    NC_000913.3 (2390048..2391505, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YfbO Neighboring gene uncharacterized protein YfbP Neighboring gene NADH:quinone oxidoreductase subunit M Neighboring gene NADH:quinone oxidoreductase subunit L Neighboring gene NADH:quinone oxidoreductase subunit K

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Energy transducing roles of antiporter-like subunits in Escherichia coli NDH-1 with main focus on subunit NuoN (ND2). Sato M, et al. J Biol Chem, 2013 Aug 23. PMID 23864658, Free PMC Article
    2. The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis. Vik SB. FEBS Lett, 2011 Apr 20. PMID 21420404
    3. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function. Michel J, et al. PLoS One, 2011 Feb 28. PMID 21387012, Free PMC Article
    4. Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I. Kaila VR, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24778264, Free PMC Article
    5. Inhibition by capsaicin of NADH-quinone oxidoreductases is correlated with the presence of energy-coupling site 1 in various organisms. Yagi T. Arch Biochem Biophys, 1990 Sep. PMID 2118334

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We observe spontaneous hydration of a putative proton entry channel at the NuoN/K interface, which is sensitive to the protonation state of buried glutamic acid residues.
      Title: Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.
    2. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
      Title: Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
    3. Data show that in L, M, and N subunits of Complex I, transmembrane helices 9 and 12 are predicted to form the discontinuous helices, which are likely to play a key role in function.
      Title: The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase (ubiquinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADH dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of respiratory chain complex I NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH:quinone oxidoreductase subunit N
    NP_416779.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2390048..2391505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416779.2 NADH:quinone oxidoreductase subunit N [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416779.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M574, A0A5D8MWC2, A0A6C9QAT4
      Conserved Domains (1) summary
      PRK05777
      Location:1 → 483
      PRK05777; NADH-quinone oxidoreductase subunit NuoN
    Nucleotide Protein
    Heading Accession and Version

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