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    hisP lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946789, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hisP
    Official Full Name
    lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit
    Primary source
    ECOCYC:EG10452
    Locus tag
    b2306
    See related
    ASAP:ABE-0007610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2300
    Summary
    HisPMQJ is an ATP-dependent histidine transport system that is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10452].
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    Genomic context

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    Sequence:
    NC_000913.3 (2423736..2424509, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene epimerase family protein YfcH Neighboring gene recombination-promoting nuclease RpnB Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisQ Neighboring gene histidine ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide-binding site of HisP, a membrane protein of the histidine permease. Identification of amino acid residues photoaffinity labeled by 8-azido-ATP. Mimura CS, et al. J Biol Chem, 1990 Nov 15. PMID 2246240
    2. Components of histidine transport: histidine-binding proteins and hisP protein. Ames GF, et al. Proc Natl Acad Sci U S A, 1970 Aug. PMID 4920090, Free PMC Article
    3. Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium. Kraft R, et al. Nucleic Acids Res, 1987 Oct 26. PMID 3313284, Free PMC Article
    4. Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport. Bishop L, et al. Proc Natl Acad Sci U S A, 1989 Sep. PMID 2674940, Free PMC Article
    5. How are the ABC transporters energized? Nikaido H. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12122215, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type amino acid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high-affinity L-histidine transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within L-histidine import across plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within L-histidine transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in amino acid import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit
    NP_416809.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2423736..2424509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416809.1 lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416809.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3KRR7
      Conserved Domains (1) summary
      PRK10619
      Location:1 → 257
      PRK10619; histidine ABC transporter ATP-binding protein HisP
    Nucleotide Protein
    Heading Accession and Version

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