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    lldR DNA-binding transcriptional dual regulator LldR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948122, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lldR
    Official Full Name
    DNA-binding transcriptional dual regulator LldR
    Primary source
    ECOCYC:EG11962
    Locus tag
    b3604
    See related
    ASAP:ABE-0011782
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3594; lct; lctR
    Summary
    LldR is a HTH GntR-type DNA-binding transcriptional regulator. [More information is available at EcoGene: EG11962]. LldR, formerly named "lactate regulator", is a transcription factor that controls expression of genes involved in transport and catabolism of L-lactate . [More information is available at EcoCyc: EG11962].
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    Genomic context

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    Sequence:
    NC_000913.3 (3779054..3779830)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene lactate/glycolate:H(+) symporter LldP Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene serine acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation. Erwin AL, et al. J Bacteriol, 1996 Aug. PMID 8759842, Free PMC Article
    2. Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli. Aguilera L, et al. J Bacteriol, 2008 Apr. PMID 18263722, Free PMC Article
    3. Mapping the xyl, mtl, and lct loci in Escherichia coli K-12. Lin RJ, et al. J Bacteriol, 1983 Nov. PMID 6313625, Free PMC Article
    4. Vinylglycolate resistance in Escherichia coli. Shaw L, et al. J Bacteriol, 1975 Mar. PMID 1090585, Free PMC Article
    5. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
      Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator LldR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3779054..3779830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418061.1 DNA-binding transcriptional dual regulator LldR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418061.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NMI8, A0A8S7NUM7
      Conserved Domains (1) summary
      PRK10421
      Location:6 → 258
      PRK10421; DNA-binding transcriptional repressor LldR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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