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    Zdhhc3 zinc finger, DHHC domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 69035, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zdhhc3provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 3provided by MGI
    Primary source
    MGI:MGI:1926134
    See related
    Ensembl:ENSMUSG00000025786 AllianceGenome:MGI:1926134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GODZ; DHHC-3; Gramp1; Zfp373; 1110020O22Rik; 1810006O10Rik; 2210017C02Rik
    Summary
    Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation of GABAergic synaptic transmission; and positive regulation of receptor localization to synapse. Acts upstream of or within protein targeting. Located in Golgi apparatus. Is expressed in central nervous system; early conceptus; genitourinary system; and ileum. Orthologous to human ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 19.6), ovary adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zdhhc3 in Genome Data Viewer
    Location:
    9 F4; 9 73.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122895224..122942269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123066159..123113194, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 15 Neighboring gene predicted gene, 35691 Neighboring gene predicted gene 9856 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 (prostate) Neighboring gene exosome component 7 Neighboring gene STARR-seq mESC enhancer starr_25557 Neighboring gene C-type lectin domain family 3, member b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TRAIL-activated apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipoprotein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoprotein localization to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC3
    Names
    GABA-A receptor-associated membrane protein 1
    acyltransferase ZDHHC3
    golgi-specific DHHC zinc finger protein
    zinc finger DHHC domain-containing protein 3
    NP_001359467.1
    NP_001359468.1
    NP_001359469.1
    NP_001359470.1
    NP_001359471.1
    NP_001359472.1
    NP_001359473.1
    NP_001359475.1
    NP_001359476.1
    NP_001359477.1
    NP_001359478.1
    NP_001359479.1
    NP_001359480.1
    NP_001359481.1
    NP_001359482.1
    NP_081193.2
    XP_006512313.1
    XP_006512314.1
    XP_006512318.1
    XP_030100417.1
    XP_036011128.1
    XP_036011129.1
    XP_036011130.1
    XP_036011132.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372538.1NP_001359467.1  palmitoyltransferase ZDHHC3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Consensus CDS
      CCDS90691.1
      UniProtKB/TrEMBL
      A0A571BEV7
      Related
      ENSMUSP00000158842.2, ENSMUST00000238520.2
      Conserved Domains (1) summary
      pfam01529
      Location:128253
      DHHC; DHHC palmitoyltransferase
    2. NM_001372539.1NP_001359468.1  palmitoyltransferase ZDHHC3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      UniProtKB/Swiss-Prot
      Q6EMK3, Q8R173
      Conserved Domains (1) summary
      pfam01529
      Location:128255
      DHHC; DHHC palmitoyltransferase
    3. NM_001372540.1NP_001359469.1  palmitoyltransferase ZDHHC3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:127254
      DHHC; DHHC palmitoyltransferase
    4. NM_001372541.1NP_001359470.1  palmitoyltransferase ZDHHC3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:121232
      DHHC; DHHC palmitoyltransferase
    5. NM_001372542.1NP_001359471.1  palmitoyltransferase ZDHHC3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:33160
      DHHC; DHHC palmitoyltransferase
    6. NM_001372543.1NP_001359472.1  palmitoyltransferase ZDHHC3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:30157
      DHHC; DHHC palmitoyltransferase
    7. NM_001372544.1NP_001359473.1  palmitoyltransferase ZDHHC3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:30157
      DHHC; DHHC palmitoyltransferase
    8. NM_001372546.1NP_001359475.1  palmitoyltransferase ZDHHC3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1101
      DHHC; DHHC palmitoyltransferase
    9. NM_001372547.1NP_001359476.1  palmitoyltransferase ZDHHC3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1101
      DHHC; DHHC palmitoyltransferase
    10. NM_001372548.1NP_001359477.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    11. NM_001372549.1NP_001359478.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    12. NM_001372550.1NP_001359479.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    13. NM_001372551.1NP_001359480.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    14. NM_001372552.1NP_001359481.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    15. NM_001372553.1NP_001359482.1  palmitoyltransferase ZDHHC3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Conserved Domains (1) summary
      pfam01529
      Location:1103
      DHHC; DHHC palmitoyltransferase
    16. NM_026917.6NP_081193.2  palmitoyltransferase ZDHHC3 isoform 2

      See identical proteins and their annotated locations for NP_081193.2

      Status: VALIDATED

      Source sequence(s)
      AC133650, AC134248
      Consensus CDS
      CCDS23654.1
      UniProtKB/Swiss-Prot
      Q6EMK3, Q8R173
      Related
      ENSMUSP00000117392.2, ENSMUST00000147563.9
      Conserved Domains (1) summary
      pfam01529
      Location:128255
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122895224..122942269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512251.3XP_006512314.1  palmitoyltransferase ZDHHC3 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:33158
      DHHC; DHHC palmitoyltransferase
    2. XM_036155236.1XP_036011129.1  palmitoyltransferase ZDHHC3 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:30155
      DHHC; DHHC palmitoyltransferase
    3. XM_036155239.1XP_036011132.1  palmitoyltransferase ZDHHC3 isoform X6

      Conserved Domains (1) summary
      pfam01529
      Location:1101
      DHHC; DHHC palmitoyltransferase
    4. XM_006512250.4XP_006512313.1  palmitoyltransferase ZDHHC3 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:113230
      DHHC; DHHC palmitoyltransferase
    5. XM_036155235.1XP_036011128.1  palmitoyltransferase ZDHHC3 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:33158
      DHHC; DHHC palmitoyltransferase
    6. XM_030244557.2XP_030100417.1  palmitoyltransferase ZDHHC3 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:33160
      DHHC; DHHC palmitoyltransferase
    7. XM_006512255.5XP_006512318.1  palmitoyltransferase ZDHHC3 isoform X7

    8. XM_036155237.1XP_036011130.1  palmitoyltransferase ZDHHC3 isoform X5