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    Tmem230 transmembrane protein 230 [ Mus musculus (house mouse) ]

    Gene ID: 70612, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem230provided by MGI
    Official Full Name
    transmembrane protein 230provided by MGI
    Primary source
    MGI:MGI:1917862
    See related
    Ensembl:ENSMUSG00000027341 AllianceGenome:MGI:1917862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730494N06Rik
    Summary
    Predicted to be involved in axonal transport and synaptic vesicle transport. Predicted to be located in endoplasmic reticulum; endosome; and trans-Golgi network. Predicted to be active in synaptic vesicle. Orthologous to human TMEM230 (transmembrane protein 230). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.1), ovary adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem230 in Genome Data Viewer
    Location:
    2 F2; 2 64.15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132081412..132089708, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132239492..132249059, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E8795 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05728 Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05733 Neighboring gene STARR-seq mESC enhancer starr_05734 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132079079-132079188 Neighboring gene expressed sequence AV099323 Neighboring gene proliferating cell nuclear antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonal transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 230
    Names
    UPF0414 transmembrane protein C20orf30 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141971.1 → NP_001135443.1  transmembrane protein 230

      See identical proteins and their annotated locations for NP_001135443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK017729, BQ922165, BY278953, BY388388
      Consensus CDS
      CCDS16770.1
      UniProtKB/Swiss-Prot
      Q8CIB6, Q9CYF7
      Related
      ENSMUSP00000136826.2, ENSMUST00000180286.2
      Conserved Domains (1) summary
      pfam05915
      Location:44 → 118
      DUF872; Eukaryotic protein of unknown function (DUF872)

    2. NM_027478.3 → NP_081754.2  transmembrane protein 230

      See identical proteins and their annotated locations for NP_081754.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK017729, BQ922165, BY278953, BY388388
      Consensus CDS
      CCDS16770.1
      UniProtKB/Swiss-Prot
      Q8CIB6, Q9CYF7
      Related
      ENSMUSP00000028816.3, ENSMUST00000028816.9
      Conserved Domains (1) summary
      pfam05915
      Location:44 → 118
      DUF872; Eukaryotic protein of unknown function (DUF872)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132081412..132089708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500166.5 → XP_006500229.1  transmembrane protein 230 isoform X1

      See identical proteins and their annotated locations for XP_006500229.1

      UniProtKB/Swiss-Prot
      Q8CIB6, Q9CYF7
      Related
      ENSMUSP00000105792.2, ENSMUST00000110163.8
      Conserved Domains (1) summary
      pfam05915
      Location:44 → 118
      DUF872; Eukaryotic protein of unknown function (DUF872)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIB6.1 GenPept UniProtKB/Swiss-Prot:Q8CIB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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