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    ttc-37 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178907, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ttc-37
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00021613
    Locus tag
    CELE_Y47A7.1
    See related
    AllianceGenome:WB:WBGene00021613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process. Predicted to be part of Ski complex. Is expressed in body wall musculature and pharynx. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human SKIC3 (SKI3 subunit of superkiller complex). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ttc-37 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (5204475..5213468)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene Venom polypeptide Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ski complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_504395.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5204475..5213468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071994.6 → NP_504395.2  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504395.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BKR2
      Conserved Domains (3) summary
      sd00006
      Location:791 → 821
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:794 → 853
      TPR_11; TPR repeat
      pfam13432
      Location:505 → 564
      TPR_16; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version

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