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    Cd151 CD151 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12476, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd151provided by MGI
    Official Full Name
    CD151 antigenprovided by MGI
    Primary source
    MGI:MGI:1096360
    See related
    Ensembl:ENSMUSG00000025510 AllianceGenome:MGI:1096360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SFA-1; PETA-3; Tspan24
    Summary
    Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 306.7), ovary adult (RPKM 269.4) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cd151 in Genome Data Viewer
    Location:
    7 F5; 7 86.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141047275..141051394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141467362..141471481)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CD151 antigen
    Names
    GP27
    membrane glycoprotein SFA-1
    platelet-endothelial tetraspan antigen 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111049.1NP_001104519.1  CD151 antigen

      See identical proteins and their annotated locations for NP_001104519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, BQ896459, DV063036, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000136331.2, ENSMUST00000177840.9
      Conserved Domains (2) summary
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15248
      Tetraspannin; Tetraspanin family
    2. NM_001111050.1NP_001104520.1  CD151 antigen

      See identical proteins and their annotated locations for NP_001104520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, CJ066904, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000061636.6, ENSMUST00000058746.7
      Conserved Domains (2) summary
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15248
      Tetraspannin; Tetraspanin family
    3. NM_009842.3NP_033972.2  CD151 antigen

      See identical proteins and their annotated locations for NP_033972.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, BQ896459, D89290, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000101622.3, ENSMUST00000106000.10
      Conserved Domains (2) summary
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15248
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141047275..141051394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)