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    Prl7d1 prolactin family 7, subfamily d, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18814, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prl7d1provided by MGI
    Official Full Name
    prolactin family 7, subfamily d, member 1provided by MGI
    Primary source
    MGI:MGI:97619
    See related
    Ensembl:ENSMUSG00000021348 AllianceGenome:MGI:97619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRP; Plfr; Ghd19; PLF-RP
    Summary
    Enables cytokine activity and hormone activity. Acts upstream of or within negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and placenta blood vessel development. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; placenta; and trophoblast giant cell. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 932.3) See more
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    Genomic context

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    See Prl7d1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27892981..27900720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27708998..27716737, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 7, subfamily a, member 2 Neighboring gene prolactin pseudogene Neighboring gene STARR-seq mESC enhancer starr_34017 Neighboring gene STARR-seq mESC enhancer starr_34018 Neighboring gene prolactin family 7, subfamily c, member 1 Neighboring gene prolactin family 2, subfamily a, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of proliferin-related protein. Colosi P, et al. Mol Endocrinol, 1988 Jun. PMID 3047555
    2. Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice. Liu Y, et al. Int J Mol Sci, 2016 Jan 13. PMID 26771609, Free PMC Article
    3. A new member of the prolactin-growth hormone gene family expressed in mouse placenta. Linzer DI, et al. EMBO J, 1985 Jun. PMID 4029117, Free PMC Article
    4. Proliferin-related protein overexpression in SGC‑7901 gastric cancer cells inhibits in vitro cell growth and tumorigenesis in nude mice. He M, et al. Oncol Rep, 2013 Jun. PMID 23589131
    5. Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein. Jackson D, et al. Science, 1994 Dec 2. PMID 7527157

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Together, this study demonstrates that Prl7d1 possesses antiangiogenic properties in deciduas and inhibits the development of junctional zone, which potentially alters the functional capacity of the placenta to support optimal fetal growth.
      Title: Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.
    2. PRL7D1 overexpression could lead to increased germ cell apoptosis and exert an inhibitory effect on testosterone production in Leydig cells by reducing the expression of certain steroidogenic-related genes.
      Title: Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
    3. Expression of PRP inhibits gastric carcinoma cell proliferation, motility, and tumorigenicity in vivo.
      Title: Proliferin-related protein overexpression in SGC‑7901 gastric cancer cells inhibits in vitro cell growth and tumorigenesis in nude mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC117676

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolactin-7D1
    Names
    growth hormone d19
    proliferin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360090.1 → NP_001347019.1  prolactin-7D1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL627326, AL732408
      Consensus CDS
      CCDS88432.1
      UniProtKB/TrEMBL
      Q9DAY8
      Related
      ENSMUSP00000021776.4, ENSMUST00000021776.4
      Conserved Domains (1) summary
      pfam00103
      Location:16 → 239
      Hormone_1; Somatotropin hormone family

    2. NM_011120.2 → NP_035250.1  prolactin-7D1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035250.1

      Status: VALIDATED

      Source sequence(s)
      AK005421, X02594
      Consensus CDS
      CCDS26405.1
      UniProtKB/Swiss-Prot
      P04769
      UniProtKB/TrEMBL
      Q5SVM4
      Related
      ENSMUSP00000153033.2, ENSMUST00000224026.2
      Conserved Domains (1) summary
      cd10288
      Location:43 → 240
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27892981..27900720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04769.1 GenPept UniProtKB/Swiss-Prot:P04769

    Gene LinkOut

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