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    Nfyb nuclear transcription factor-Y beta [ Mus musculus (house mouse) ]

    Gene ID: 18045, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nfybprovided by MGI
    Official Full Name
    nuclear transcription factor-Y betaprovided by MGI
    Primary source
    MGI:MGI:97317
    See related
    Ensembl:ENSMUSG00000020248 AllianceGenome:MGI:97317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbf-A
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; early conceptus; genitourinary system; and nervous system. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.1), CNS E14 (RPKM 12.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nfyb in Genome Data Viewer
    Location:
    10 C1; 10 40.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82584534..82599985, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82748700..82764151, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10632 Neighboring gene STARR-positive B cell enhancer ABC_E6890 Neighboring gene STARR-positive B cell enhancer ABC_E578 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6 Neighboring gene STARR-seq mESC enhancer starr_27366 Neighboring gene thymine DNA glycosylase Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:82129373-82129482 Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8353 Neighboring gene STARR-seq mESC enhancer starr_27367 Neighboring gene STARR-seq mESC enhancer starr_27368 Neighboring gene host cell factor C2 Neighboring gene STARR-positive B cell enhancer ABC_E6891 Neighboring gene STARR-seq mESC enhancer starr_27374 Neighboring gene RIKEN cDNA 1700028I16 gene Neighboring gene STARR-seq mESC enhancer starr_27375 Neighboring gene STARR-seq mESC enhancer starr_27376 Neighboring gene STARR-positive B cell enhancer ABC_E9798 Neighboring gene STARR-seq mESC enhancer starr_27377 Neighboring gene thioredoxin reductase 1 Neighboring gene STARR-seq mESC enhancer starr_27378 Neighboring gene predicted gene, 38560

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear transcription factor Y subunit beta
    Names
    CAAT box DNA-binding protein subunit B
    NF-YB
    nuclear transcription factor Y subunit B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428686.1NP_001415615.1  nuclear transcription factor Y subunit beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC155709
      UniProtKB/Swiss-Prot
      P22569, P63139, Q3UK54
      UniProtKB/TrEMBL
      Q9D056
    2. NM_001428687.1NP_001415616.1  nuclear transcription factor Y subunit beta isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155709
    3. NM_010914.3NP_035044.1  nuclear transcription factor Y subunit beta isoform a

      See identical proteins and their annotated locations for NP_035044.1

      Status: VALIDATED

      Source sequence(s)
      AC155709
      Consensus CDS
      CCDS48654.1
      UniProtKB/Swiss-Prot
      P22569, P63139, Q3UK54
      UniProtKB/TrEMBL
      Q9D056
      Related
      ENSMUSP00000122403.2, ENSMUST00000130911.8
      Conserved Domains (1) summary
      pfam00808
      Location:57122
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      82584534..82599985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243380.3XP_011241682.1  nuclear transcription factor Y subunit beta isoform X2

      Conserved Domains (1) summary
      pfam00808
      Location:247
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    2. XM_011243379.4XP_011241681.1  nuclear transcription factor Y subunit beta isoform X1

      Conserved Domains (1) summary
      pfam00808
      Location:57122
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    3. XM_011243381.4XP_011241683.1  nuclear transcription factor Y subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011241683.1

      Conserved Domains (1) summary
      pfam00808
      Location:247
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone