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    garD GarD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947641, updated on 17-Dec-2024

    Summary

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    Official Symbol
    garD
    Official Full Name
    GarD
    Primary source
    ECOCYC:EG12522
    Locus tag
    b3128
    See related
    ASAP:ABE-0010284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3116; yhaG
    Summary
    Galactarate dehydratase catalyzes the dehydration of galactarate, the naturally occurring dicarboxylic acid analogue of D-galactose . [More information is available at EcoCyc: EG12522].
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    Genomic context

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    Sequence:
    NC_000913.3 (3275282..3276853)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene alpha-dehydro-beta-deoxy-D-glucarate aldolase Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene antitoxin PrlF Neighboring gene ribosome-dependent mRNA interferase toxin YhaV Neighboring gene DNA-binding transcriptional repressor AgaR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric dehydration of galactarate by bacterial galactarate dehydratase. Blumenthal HJ, et al. Biochem Biophys Res Commun, 1964 Oct 14. PMID 4285952
    2. Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype. Baird L, et al. J Bacteriol, 1990 Mar. PMID 2407727, Free PMC Article
    3. Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment. Rosas-Lemus M, et al. Protein Sci, 2020 Mar. PMID 31811683, Free PMC Article
    4. A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. Monterrubio R, et al. J Bacteriol, 2000 May. PMID 10762278, Free PMC Article
    5. Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. Hubbard BK, et al. Biochemistry, 1998 Oct 13. PMID 9772162

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactarate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactarate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactarate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-galacturonate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactarate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GarD
    NP_417597.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3275282..3276853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417597.1 GarD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417597.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NWC9
      Conserved Domains (1) summary
      TIGR03248
      Location:15 → 523
      galactar-dH20; galactarate dehydratase
    Nucleotide Protein
    Heading Accession and Version

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