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    Isg15 ISG15 ubiquitin-like modifier [ Mus musculus (house mouse) ]

    Gene ID: 100038882, updated on 9-Dec-2024

    Summary

    Official Symbol
    Isg15provided by MGI
    Official Full Name
    ISG15 ubiquitin-like modifierprovided by MGI
    Primary source
    MGI:MGI:1855694
    See related
    Ensembl:ENSMUSG00000035692 AllianceGenome:MGI:1855694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G1p2; IP17; Irfp; UCRP; IGI15
    Summary
    Enables protein tag activity. Involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; decidua; embryo; labyrinthine zone; and mesometrium. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 20.5), placenta adult (RPKM 4.4) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Isg15 in Genome Data Viewer
    Location:
    4 E2; 4 88.61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156283881..156285275, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156199424..156200818, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger 223 Neighboring gene STARR-seq mESC enhancer starr_12288 Neighboring gene STARR-seq mESC enhancer starr_12289 Neighboring gene agrin Neighboring gene STARR-seq mESC enhancer starr_12290 Neighboring gene STARR-seq mESC enhancer starr_12291 Neighboring gene predicted gene, 46878 Neighboring gene STARR-positive B cell enhancer ABC_E2735 Neighboring gene expressed sequence AW011738 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene predicted gene, 46877

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC18616, MGC103144, MGC130321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tag activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ISG15-protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ISG15-protein conjugation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ISG15-protein conjugation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within modification-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein oligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type I interferon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like protein ISG15
    Names
    interferon, alpha-inducible protein
    interferon-induced 15 kDa protein
    interferon-induced 15-KDa protein
    interferon-induced 17 kDa protein
    interferon-stimulated protein (15 kDa)
    interferon-stimulated protein 15
    ubiquitin cross-reactive protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015783.3NP_056598.2  ubiquitin-like protein ISG15

      See identical proteins and their annotated locations for NP_056598.2

      Status: VALIDATED

      Source sequence(s)
      CT998563
      Consensus CDS
      CCDS51405.1
      UniProtKB/Swiss-Prot
      Q64339, Q8K0H3
      UniProtKB/TrEMBL
      Q4FJR9
      Related
      ENSMUSP00000082548.5, ENSMUST00000085425.6
      Conserved Domains (2) summary
      cd01792
      Location:375
      Ubl1_ISG15; ubiquitin-like (Ubl) domain 1 found in interferon-stimulated gene 15 (ISG15) and similar proteins
      cd01810
      Location:80153
      Ubl2_ISG15; ubiquitin-like (Ubl) domain 2 found in interferon-stimulated gene 15 (ISG15) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156283881..156285275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)