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    Nr1d2 nuclear receptor subfamily 1, group D, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 353187, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nr1d2provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group D, member 2provided by MGI
    Primary source
    MGI:MGI:2449205
    See related
    Ensembl:ENSMUSG00000021775 AllianceGenome:MGI:2449205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RVR; Rev-erb
    Summary
    This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in bladder adult (RPKM 22.5), cerebellum adult (RPKM 19.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nr1d2 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4230549..4265639)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18204056..18239106, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 Neighboring gene STARR-seq mESC enhancer starr_36048 Neighboring gene predicted gene 7084 Neighboring gene STARR-seq mESC enhancer starr_36047 Neighboring gene predicted gene, 44469 Neighboring gene STARR-positive B cell enhancer mm9_chr14:18999596-18999897 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear receptor subfamily 1 group D member 2
    Names
    Rev-erb beta
    orphan nuclear receptor RVR
    rev-erb-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425894.1NP_001412823.1  nuclear receptor subfamily 1 group D member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    2. NM_001425895.1NP_001412824.1  nuclear receptor subfamily 1 group D member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    3. NM_001425896.1NP_001412825.1  nuclear receptor subfamily 1 group D member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    4. NM_001425897.1NP_001412826.1  nuclear receptor subfamily 1 group D member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    5. NM_001425898.1NP_001412827.1  nuclear receptor subfamily 1 group D member 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    6. NM_001425900.1NP_001412829.1  nuclear receptor subfamily 1 group D member 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    7. NM_001425901.1NP_001412830.1  nuclear receptor subfamily 1 group D member 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    8. NM_001425902.1NP_001412831.1  nuclear receptor subfamily 1 group D member 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      CU024892
      UniProtKB/TrEMBL
      Q8C598
    9. NM_001425903.1NP_001412832.1  nuclear receptor subfamily 1 group D member 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CU024892
    10. NM_001425904.1NP_001412833.1  nuclear receptor subfamily 1 group D member 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CU024892
    11. NM_011584.5NP_035714.3  nuclear receptor subfamily 1 group D member 2 isoform 1

      See identical proteins and their annotated locations for NP_035714.3

      Status: VALIDATED

      Source sequence(s)
      CU024892
      Consensus CDS
      CCDS36811.1
      UniProtKB/Swiss-Prot
      Q60646, Q60674
      UniProtKB/TrEMBL
      Q4VAB7, Q8C598
      Related
      ENSMUSP00000088031.6, ENSMUST00000090543.6
      Conserved Domains (2) summary
      cd06940
      Location:386574
      NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
      cd07166
      Location:98186
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      4230549..4265639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158687.1XP_036014580.1  nuclear receptor subfamily 1 group D member 2 isoform X1

      UniProtKB/TrEMBL
      Q8C598
      Conserved Domains (2) summary
      cd07166
      Location:98186
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
      cl11397
      Location:386512
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RNA

    1. XR_004938413.1 RNA Sequence

    2. XR_004938414.1 RNA Sequence