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    Sstr5 somatostatin receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 20609, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sstr5provided by MGI
    Official Full Name
    somatostatin receptor 5provided by MGI
    Primary source
    MGI:MGI:894282
    See related
    Ensembl:ENSMUSG00000050824 AllianceGenome:MGI:894282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sst5; Smstr5
    Summary
    Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Is expressed in brain; cochlea; cochlear duct epithelium; cochlear ganglion; and organ of Corti. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Sstr5 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25708849..25716262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25489875..25497288, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene tektin 4 Neighboring gene predicted gene, 53993 Neighboring gene predicted gene, 33727 Neighboring gene predicted gene, 33801

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables somatostatin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables somatostatin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables somatostatin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatostatin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    somatostatin receptor type 5
    Names
    SS-5-R
    SS5-R
    SS5R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191008.1NP_001177937.1  somatostatin receptor type 5

      See identical proteins and their annotated locations for NP_001177937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131323, AK133767
      Consensus CDS
      CCDS28520.1
      UniProtKB/Swiss-Prot
      A6H6N8, O08858, O08998, Q3UZM7
      UniProtKB/TrEMBL
      A0AAA9WUV9
      Related
      ENSMUSP00000128787.3, ENSMUST00000165183.11
      Conserved Domains (2) summary
      pfam00001
      Location:54303
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48227
      7tm_4; Olfactory receptor
    2. NM_011425.3NP_035555.1  somatostatin receptor type 5

      See identical proteins and their annotated locations for NP_035555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131323, AK133609
      Consensus CDS
      CCDS28520.1
      UniProtKB/Swiss-Prot
      A6H6N8, O08858, O08998, Q3UZM7
      UniProtKB/TrEMBL
      A0AAA9WUV9
      Related
      ENSMUSP00000051085.5, ENSMUST00000051864.6
      Conserved Domains (2) summary
      pfam00001
      Location:54303
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48227
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25708849..25716262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)