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    Hpca hippocalcin [ Mus musculus (house mouse) ]

    Gene ID: 15444, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hpcaprovided by MGI
    Official Full Name
    hippocalcinprovided by MGI
    Primary source
    MGI:MGI:1336200
    See related
    Ensembl:ENSMUSG00000028785 AllianceGenome:MGI:1336200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including actin binding activity; calcium ion binding activity; and identical protein binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Predicted to be active in glutamatergic synapse and postsynapse. Is expressed in ganglia; salivary gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 184.5), frontal lobe adult (RPKM 103.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hpca in Genome Data Viewer
    Location:
    4 D2.2; 4 62.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129005363..129019712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129111570..129125919, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene STARR-positive B cell enhancer ABC_E4669 Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to L-glutamate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to Aroclor 1254 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ketamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuron-specific calcium-binding protein hippocalcin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130419.3NP_001123891.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      See identical proteins and their annotated locations for NP_001123891.1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS18682.1
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000129548.2, ENSMUST00000164649.8
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. NM_001286081.2NP_001273010.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      See identical proteins and their annotated locations for NP_001273010.1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS18682.1
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000119178.3, ENSMUST00000139450.8
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    3. NM_001286083.2NP_001273012.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      See identical proteins and their annotated locations for NP_001273012.1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS18682.1
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    4. NM_001421088.1NP_001408017.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
    5. NM_001421089.1NP_001408018.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
    6. NM_001421090.1NP_001408019.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
    7. NM_001421091.1NP_001408020.1  neuron-specific calcium-binding protein hippocalcin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606977
      UniProtKB/TrEMBL
      E9PV73
    8. NM_001421092.1NP_001408021.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000112143.3, ENSMUST00000116442.9
    9. NM_010471.5NP_034601.1  neuron-specific calcium-binding protein hippocalcin isoform 1

      See identical proteins and their annotated locations for NP_034601.1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS18682.1
      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000030572.4, ENSMUST00000030572.10
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RNA

    1. NR_185239.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606977
    2. NR_185240.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606977
    3. NR_185241.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606977

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129005363..129019712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253224.1XP_030109084.1  neuron-specific calcium-binding protein hippocalcin isoform X1

      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. XM_006502775.4XP_006502838.1  neuron-specific calcium-binding protein hippocalcin isoform X1

      See identical proteins and their annotated locations for XP_006502838.1

      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Related
      ENSMUSP00000112145.3, ENSMUST00000116444.10
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    3. XM_030253225.1XP_030109085.1  neuron-specific calcium-binding protein hippocalcin isoform X1

      UniProtKB/Swiss-Prot
      A2A7R4, P84075
      UniProtKB/TrEMBL
      E9PV73
      Conserved Domains (1) summary
      COG5126
      Location:13179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]