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    mrr Type IV methyl-directed restriction enzyme EcoKMrr [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948898, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mrr
    Official Full Name
    Type IV methyl-directed restriction enzyme EcoKMrr
    Primary source
    ECOCYC:EG10612
    Locus tag
    b4351
    See related
    ASAP:ABE-0014271
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4341
    Summary
    The N-terminus of overexpressed Mrr was determined, but the native RBS was not used. [More information is available at EcoGene: EG10612]. Mrr is a type IV restriction endonuclease involved in restriction of N6-adenine-methylated DNA and C5-cytosine-methylated DNA . [More information is available at EcoCyc: EG10612].
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    Genomic context

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    Sequence:
    NC_000913.3 (4586949..4587863)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene type I restriction enzyme EcoKI specificity subunit Neighboring gene type I restriction enzyme EcoKI methylase subunit Neighboring gene type I restriction enzyme EcoKI endonuclease subunit Neighboring gene P-loop guanosine triphosphatase YjiA Neighboring gene PF04328 family protein YjiX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mrr instigates the SOS response after high pressure stress in Escherichia coli. Aertsen A, et al. Mol Microbiol, 2005 Dec. PMID 16313623
    2. Identification and characterization of a gene responsible for inhibiting propagation of methylated DNA sequences in mcrA mcrB1 Escherichia coli strains. Kretz PL, et al. J Bacteriol, 1991 Aug. PMID 1649819, Free PMC Article
    3. A novel activity in Escherichia coli K-12 that directs restriction of DNA modified at CG dinucleotides. Kelleher JE, et al. J Bacteriol, 1991 Aug. PMID 1830580, Free PMC Article
    4. Site-specific methylases induce the SOS DNA repair response in Escherichia coli. Heitman J, et al. J Bacteriol, 1987 Jul. PMID 3036779, Free PMC Article
    5. An oligomeric switch controls the Mrr-induced SOS response in E. coli. Bourges AC, et al. DNA Repair (Amst), 2021 Jan. PMID 33220536

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An oligomeric switch controls the Mrr-induced SOS response in E. coli.
      Title: An oligomeric switch controls the Mrr-induced SOS response in E. coli.
    2. Mrr of E. coli MG1655 causes distinct genotoxicity when expressed in Salmonella typhimurium LT2.
      Title: Evidence for an evolutionary antagonism between Mrr and Type III modification systems.
    3. In this report they used high pressure to isolate and analyze several Mrr mutants, and generated a new structural model of the Mrr protein.
      Title: Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr.
    4. evidence of a novel stress-induced pathway that links the physical perception of high hydrostatic pressure to the induction of an SOS response through activation of Mrr
      Title: Mrr instigates the SOS response after high pressure stress in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables restriction endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables restriction endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables type IV site-specific deoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA restriction-modification system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hydrostatic pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in bacterial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bacterial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Type IV methyl-directed restriction enzyme EcoKMrr

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4586949..4587863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418771.1 Type IV methyl-directed restriction enzyme EcoKMrr [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418771.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377APU0
      Conserved Domains (1) summary
      COG1715
      Location:1 → 304
      Mrr; Restriction endonuclease Mrr [Defense mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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