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    yigB 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948357, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yigB
    Official Full Name
    5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
    Primary source
    ECOCYC:EG11202
    Locus tag
    b3812
    See related
    ASAP:ABE-0012450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3807
    Summary
    HAD superfamily. [More information is available at EcoGene: EG11202]. YigB is an FMN phosphatase that belongs to the superfamily of haloacid dehalogenase (HAD)-like hydrolases . yigB is important for formation of dormant persister cells; overexpression of yigB leads to increased tolerance to ofloxacin . [More information is available at EcoCyc: EG11202].
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    Genomic context

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    Sequence:
    NC_000913.3 (3997183..3997899)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA Neighboring gene site-specific tyrosine recombinase Neighboring gene DNA helicase II Neighboring gene DUF2233 domain-containing protein YigE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide sequence of the uvrD gene of E. coli. Finch PW, et al. Nucleic Acids Res, 1984 Jul 25. PMID 6379604, Free PMC Article
    2. Transcription of the uvrD gene of Escherichia coli is controlled by the lexA repressor and by attenuation. Easton AM, et al. Nucleic Acids Res, 1983 Dec 20. PMID 6324092, Free PMC Article
    3. Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis. Haase I, et al. Chembiochem, 2013 Nov 25. PMID 24123841
    4. Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases. Colloms SD, et al. J Bacteriol, 1990 Dec. PMID 2254268, Free PMC Article
    5. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Hansen S, et al. Antimicrob Agents Chemother, 2008 Aug. PMID 18519731, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
    NP_418257.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3997183..3997899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418257.1 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418257.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7H9SJS0
      Conserved Domains (1) summary
      PRK10748
      Location:1 → 238
      PRK10748; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB
    Nucleotide Protein
    Heading Accession and Version

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