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    dgcE putative diguanylate cyclase DgcE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946600, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcE
    Official Full Name
    putative diguanylate cyclase DgcE
    Primary source
    ECOCYC:EG12396
    Locus tag
    b2067
    See related
    ASAP:ABE-0006845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2061; yegE
    Summary
    A yegE null mutation partially suppresses the motility defect of a yhjH mutation; yegE partial suppression is best at 28C, full yhjH suppression requires yegE and yedQ mutations; a yeaJ null mutation is a better yhjH suppressor at 37C; full yhjH suppression requires yegE, yedQ and yeaJ null mutations when grown at 37C (Pesavento, 2008). [More information is available at EcoGene: EG12396]. YegE is a GGDEF/EAL protein that is involved in regulation of the switch from flagellar motility to sessile behavior and curli expression . [More information is available at EcoCyc: EG12396].
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    Genomic context

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    Sequence:
    NC_000913.3 (2143266..2146583)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dCTP deaminase Neighboring gene uridine/cytidine kinase Neighboring gene DNA-3-methyladenine glycosylase 2 Neighboring gene HSP70 family protein YegD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. Sarenko O, et al. mBio, 2017 Oct 10. PMID 29018125, Free PMC Article
    2. Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents. Nakabeppu Y, et al. J Biol Chem, 1984 Nov 25. PMID 6094528
    3. A comprehensive genetic characterization of bacterial motility. Girgis HS, et al. PLoS Genet, 2007 Sep. PMID 17941710, Free PMC Article
    4. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative diguanylate cyclase DgcE
    NP_416571.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2143266..2146583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416571.1 putative diguanylate cyclase DgcE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416571.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A779QBG9
      Conserved Domains (1) summary
      PRK09776
      Location:20 → 1105
      PRK09776; putative diguanylate cyclase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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