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    srmB ATP-dependent RNA helicase SrmB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947055, updated on 3-Dec-2024

    Summary

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    Official Symbol
    srmB
    Official Full Name
    ATP-dependent RNA helicase SrmB
    Primary source
    ECOCYC:EG10975
    Locus tag
    b2576
    See related
    ASAP:ABE-0008478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2574; rbaB; rhlA
    Summary
    The SrmB protein facilitates an early step in the assembly of the 50S subunit of the ribosome . [More information is available at EcoCyc: EG10975].
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    Genomic context

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    Sequence:
    NC_000913.3 (2712896..2714230)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene rpoE leader peptide Neighboring gene L-aspartate oxidase Neighboring gene tRNA m(6)A37 methyltransferase Neighboring gene putative LysR-type DNA-binding transcriptional regulator YfiE Neighboring gene cysteine/O-acetylserine exporter EamB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of ribosome assembly in Escherichia coli ribosomal RNA degradation. Jain C. Nucleic Acids Res, 2018 Nov 16. PMID 30219894, Free PMC Article
    2. A DEAD-box protein regulates ribosome assembly through control of ribosomal protein synthesis. Iost I, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31188443, Free PMC Article
    3. Identification of the sites of action of SrmB, a DEAD-box RNA helicase involved in Escherichia coli ribosome assembly. Proux F, et al. Mol Microbiol, 2011 Oct. PMID 21859437
    4. DEAD-box proteins from Escherichia coli exhibit multiple ATP-independent activities. Zhao X, et al. J Bacteriol, 2011 May. PMID 21378185, Free PMC Article
    5. An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. Nishi K, et al. Nature, 1988 Dec 1. PMID 2461520

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate a specific mechanism for DEAD-box proteins (DBPs) RNA helicase SrmB (SrmB) regulation of ribosomal assembly, indirectly mediated through its effects on r-protein expression.
      Title: A DEAD-box protein regulates ribosome assembly through control of ribosomal protein synthesis.
    2. SrmB acts on rRNA regions that are distinct from its binding site.
      Title: Identification of the sites of action of SrmB, a DEAD-box RNA helicase involved in Escherichia coli ribosome assembly.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosomal large subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcriptional attenuation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase SrmB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2712896..2714230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417071.1 ATP-dependent RNA helicase SrmB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417071.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QTL2, A0A8S7QJJ2
      Conserved Domains (1) summary
      PRK11192
      Location:18 → 435
      PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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