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    ler transcription regulator Ler [ Escherichia coli O157:H7 str. Sakai ]

    Gene ID: 915445, updated on 17-Dec-2024

    Summary

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    Gene symbol
    ler
    Gene description
    transcription regulator Ler
    Locus tag
    ECs_4588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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    Genomic context

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    Sequence:
    NC_002695.2 (4619911..4620282, complement)

    NC_002695.2Genomic Context describing neighboring genes Neighboring gene T3SS component Neighboring gene T3SS component Neighboring gene T3SS component Neighboring gene T3SS secreted effector EspG Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002695.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The global regulator Ler is necessary for enteropathogenic Escherichia coli colonization of Caenorhabditis elegans. Mellies JL, et al. Infect Immun, 2006 Jan. PMID 16368958, Free PMC Article
    2. Role of hha and ler in transcriptional regulation of the esp operon of enterohemorrhagic Escherichia coli O157:H7. Sharma VK, et al. J Bacteriol, 2004 Nov. PMID 15489441, Free PMC Article
    3. RNA-binding protein Hfq downregulates locus of enterocyte effacement-encoded regulators independent of small regulatory RNA in enterohemorrhagic Escherichia coli. Sudo N, et al. Mol Microbiol, 2022 Jan. PMID 34411346
    4. [Construction and immunization of a enterohemorrhagic Escherichia coli O157 attenuated]. Liu J, et al. Sheng Wu Gong Cheng Xue Bao, 2007 Mar. PMID 17460890
    5. Concert of regulators to switch on LEE expression in enterohemorrhagic Escherichia coli O157:H7: interplay between Ler, GrlA, HNS and RpoS. Laaberki MH, et al. Int J Med Microbiol, 2006 Aug. PMID 16618552

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein Hfq downregulates locus of enterocyte effacement-encoded regulators independent of small regulatory RNA in enterohemorrhagic Escherichia coli.
      Title: RNA-binding protein Hfq downregulates locus of enterocyte effacement-encoded regulators independent of small regulatory RNA in enterohemorrhagic Escherichia coli.
    2. Study demonstrated that O157 ler/stx deletion mutant lost the toxigenicity to vero cell and to be safety to mice, and this mutant strain could be used as an attenuated vaccine candidate against EHEC O157.
      Title: [Construction and immunization of a enterohemorrhagic Escherichia coli O157 attenuated].
    3. Deletion of the gene encoding the global regulator Ler severely reduces the ability of enteropathogenic Escherichia coli to colonize the nematode gut
      Title: The global regulator Ler is necessary for enteropathogenic Escherichia coli colonization of Caenorhabditis elegans.
    4. hha-mediated repression of ler causes reduced expression of the esp operon.
      Title: Role of hha and ler in transcriptional regulation of the esp operon of enterohemorrhagic Escherichia coli O157:H7.
    5. data demonstrate that the locus of enterocyte effacement (LEE) expression can be turned on by at least two separate pathways, DsrA/RpoS and HNS/GrlA, acting on the transcription of ler
      Title: Concert of regulators to switch on LEE expression in enterohemorrhagic Escherichia coli O157:H7: interplay between Ler, GrlA, HNS and RpoS.
    6. LEE transcriptional regulator Ler was activated by ppGpp and was essential for the enhancement of LEE gene expression.
      Title: ppGpp with DksA controls gene expression in the locus of enterocyte effacement (LEE) pathogenicity island of enterohaemorrhagic Escherichia coli through activation of two virulence regulatory genes.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    transcription regulator Ler

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002695.2 Reference assembly

      Range
      4619911..4620282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_312615.2 transcription regulator Ler [Escherichia coli O157:H7 str. Sakai]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3JQJ3, A0A4P8B1W0, A0A4P8BZJ3, O85645
      Conserved Domains (1) summary
      COG2916
      Location:1 → 111
      Hns; DNA-binding protein H-NS [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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