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    tdh threonine dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948139, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tdh
    Official Full Name
    threonine dehydrogenase
    Primary source
    ECOCYC:EG10993
    Locus tag
    b3616
    See related
    ASAP:ABE-0011830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3606
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    Genomic context

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    Sequence:
    NC_000913.3 (3790320..3791345, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein hydrolase activator EnvC Neighboring gene divergent polysaccharide deacetylase domain-containing protein YibQ Neighboring gene UDP-glucuronate:LPS(HepIII) glycosyltransferase Neighboring gene 2-amino-3-ketobutyrate CoA ligase Neighboring gene protein HtrL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12. Boylan SA, et al. J Biol Chem, 1981 Feb 25. PMID 6780553
    2. L-Threonine dehydrogenase of Escherichia coli K-12. Boylan SA, et al. Biochem Biophys Res Commun, 1978 Nov 14. PMID 33672
    3. L-threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies. Epperly BR, et al. J Biol Chem, 1991 Apr 5. PMID 2007567
    4. The sulfhydryl content of L-threonine dehydrogenase from Escherichia coli K-12: relation to catalytic activity and Mn2+ activation. Craig PA, et al. Biochim Biophys Acta, 1990 Jan 19. PMID 2104757
    5. Inactivation of Escherichia coli L-threonine dehydrogenase by 2,3-butanedione. Evidence for a catalytically essential arginine residue. Epperly BR, et al. J Biol Chem, 1989 Nov 5. PMID 2681195

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that peptide deformylase, threonine dehydrogenase, and cytosine deaminase are very sensitve to hydrogen peroxide.
      Title: Mononuclear iron enzymes are primary targets of hydrogen peroxide stress.
    2. N-terminus verified by Edman degradation on complete protein
      Title: The primary structure of Escherichia coli L-threonine dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-threonine 3-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-threonine 3-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-serine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-threonine catabolic process to glycine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine dehydrogenase
    NP_418073.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3790320..3791345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418073.1 threonine dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418073.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7L585
      Conserved Domains (1) summary
      PRK05396
      Location:1 → 341
      tdh; L-threonine 3-dehydrogenase; Validated
    Nucleotide Protein
    Heading Accession and Version

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