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    cueR DNA-binding transcriptional dual regulator CueR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945332, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cueR
    Official Full Name
    DNA-binding transcriptional dual regulator CueR
    Primary source
    ECOCYC:G6263
    Locus tag
    b0487
    See related
    ASAP:ABE-0001693
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    copR; ECK0481; ybbI
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    Genomic context

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    Sequence:
    NC_000913.3 (513993..514400)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutaminase 1 Neighboring gene putative transporter YbaT Neighboring gene NfeD-like family protein YbbJ Neighboring gene PHB domain-containing protein QmcA Neighboring gene putative iron ABC exporter ATP-binding subunit FetA Neighboring gene putative iron ABC exporter membrane subunit FetB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CueR activates transcription through a DNA distortion mechanism. Fang C, et al. Nat Chem Biol, 2021 Jan. PMID 32989300, Free PMC Article
    2. TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter. Philips SJ, et al. Science, 2015 Aug 21. PMID 26293965, Free PMC Article
    3. Single-molecule study of metalloregulator CueR-DNA interactions using engineered Holliday junctions. Andoy NM, et al. Biophys J, 2009 Aug 5. PMID 19651042, Free PMC Article
    4. Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR. Balogh RK, et al. Chembiochem, 2022 Aug 17. PMID 35714117, Free PMC Article
    5. An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein. Chen K, et al. J Am Chem Soc, 2003 Oct 8. PMID 14518983

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR.
      Title: Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR.
    2. CueR activates transcription through a DNA distortion mechanism.
      Title: CueR activates transcription through a DNA distortion mechanism.
    3. Data indicate that RNAP sigma(70)-can bind to copper efflux regulator (CueR)-promoter PcopA complex.
      Title: Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcription.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator CueR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      513993..514400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415020.1 DNA-binding transcriptional dual regulator CueR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415020.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2G3D4, A0A5B9AKM8
      Conserved Domains (1) summary
      PRK10227
      Location:1 → 135
      PRK10227; HTH-type transcriptional regulator CueR
    Nucleotide Protein
    Heading Accession and Version

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